Hyperlipemia, alimentary

Fat. The alimentary hyperlipemia following the administration of a standard fat-containing meal can be measured by various... 

DNA synthesis inhibition. Ethanol (90%) extract of the dried entire plant at a concentration of 0.25 mg/mL, was active " " ". Fibrinolytic activity. Ether extracts of the dried gum and gum resin, administered orally to 10 healthy subjects fed 100 g of butter to produce alimentary hyperlipemia, were active " "". ... 

Gas Chromatographic Studies of Serum Fatty Acids of Man, IV. The Alimentary Hyperlipemia After Various Dietary Fats... 

Fat-induced hyperlipemia (FIHL), hyperchylomicronemia, type I of Fredrickson and Lees, alimentary hyperglyceridemia]. 

Limitation of fat intake represents the most effective tool in exogenous hyperlipemia. The amount of fat tolerated will vary in different individuals, but probably should never exceed 15% of total calories. The kind of fat seems to be of minor importance with regard to control of exogenous hyperlipemia but in view of the fat restriction a sufficient intake of linoleate should be assured. Wilkinson (1956), because of the delayed clearing of alimentary fat, has recommended a program of spaced fat feeding (one fat meal per day). Medium chain triglyceride has been recommended by Ahrens and Spritz (1963) and Furman et al. (1963) because of its absorption into the portal circulation (Bloom et al. 1951) and consequent lack of contribution to chylomicron formation (Job ST and Schett-LER 1956). 

The lipids in the blood during fasting consist largely of phospholipids, cholesterol, and cholesterol esters and almost no triglycerides. After a fat meal, glycerides in the blood increase 300 to 500 mg. per 100 ml. Maximum hyperlipemia is observed 23 to 3 hr. after ingestion of a moderate amount of fat and the fasting level is attained by the fifth hour (Chapter 7). Hyperlipemia depends upon the rate of removal of fat from the blood as well as on the rate of intake. Administration of heparin has been shown to prevent normal alimentary lipemia. This action may be related to the beneficial effect of heparin reported by Jones and associates in patients with atherosclerosis, namely, reduction in the level of certain lipoproteins in the blood. 

Finally it should be noted that induced alimentary hyperlipemia also favours the adhesion of platelets in in vitro and in vivo systems (12,33,35). 

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