Hypercholesterolemic effects

Beynen. The hypercholesterolemic effect of dietary coconut fat versus com CN116 oil in hypo- or hyperresponsive rabbits is not exerted through influencing cholesterol absorption. Lipids 1991 CN117... 

PO042 Williams, C. L., M. Bollella, A. Spark, and D. Puder. Soluble fiber enhances the hypercholesterolemic effect of the PO054 step 1 diet in childhood. J Amer Coll Nutr 1995 14(3) 251-257. 

Sauvaire, Y., Ribes, G., Baccou, J., and Loubatieres-Mariani, M. 1991. Implication of steroid saponins and sapogenins in the hypercholesterolemic effect of fenugreek. Lipids 26, 191-197. 

The effect different fatty acids have on cholesterolemia is well known. Whatever the kind of the effect (hyper- or hypocholesterolemic), it seems to be more pronounced when the fatty acids are esterified at the inner than at the outer positions of TAGs. The lower hypercholesterolemic effect of saturated fatty acids at the outer positions (64) can be the result of a combination of different factors such as reduced absorption by unabsorbable soap formation, which in turn interferes with cholesterol absorption in the intestinal lumen, partial desaturation and oxidation in the small intestinal cells, and reduced targeting into the fiver (63). The stronger hypocholesterolemic effect of polyunsamrated fatty acids at the i -2-position (65) could be the result of increased influx in the liver (66). 

As important as these results may be to an understanding of the hypercholesterolemic effect which Furda discusses, we should not allow their potential significance in iron bioavailability to pass unnoticed. We would like to suggest, in fact, that such reactions could explain, in part, the seemingly greater bioavailability, often seen with ferrous iron in comparison to ferric iron. Perhaps there is a general tendency for the trivalent ion, Fe3+,... 

Figure 18 Anti-hypercholesterolemic effect of DIIA-rich Chlorella in rats fed high cholesterol diet. DHA contents of DHA-rich Chlorella, DHA oil, and Chlorella diet are 0.8 %. 0.8 %, and 0 %, respectively. Values are mcnas SD. Significantly different from the basal group (P<005) S Significantly different from the DHA-rich Chlorella group (P<0.05).

Significant reduction in serum cholesterol levels can also be demonstrated in animals simultaneously fed polyenes and high sterol diets. Dogs appeared more able to maintain their serum cholesterol levels when fed sterols and filipin, amphotericin B or candicidin [145,535] but nystatin had no effect. The anti-hypercholesterolemic effect was not simply due to the prevention of sterol uptake [538,539]. A consequence of the excretion of sterol-polyene complexes in the faeces is the loss of bile salts (which are steroids) and this tends to remove sterol from the body. This resulted in increased hepatic synthesis, increased utilization of adipose fat and reduced sebum levels. Candicidin has been suggested as an antihypercholesterolemic agent in man [546]. 

Triton is a detergent and like cholic acid, which is an endogenous detergent, it causes hypercholesterolemia in the rat when injected intravenously. The water-soluble triton WR-1339, as supplied by the Roehm and Hass Company, is a polymeric -isooctyl-polyoxy-ethylenephenol. The hyperlipemic and hypercholesterolemic effect of triton was first observed in the rabbit by Kellner et al. [242]. The triton-effect in the rat has been further elaborated by Friedman and Byers [243]. 

Rats on 0.5 % cholesterol 15 mg% capsaicin produced anti-hypercholesterolemic effect [105]... 

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