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Hypercalcemia gallium nitrate

Gallium nitrate is approved by the FDA for the management of hypercalcemia of malignancy. This drug acts by inhibiting... [Pg.966]

Gallium nitrate is used clinically, at lower doses than for treating tumors, to treat hypercalcemia associated with bone cancers. " It incorporates into bone at very low levels and prevents calcium resorption, leading also to higher phosphate and collagen levels, and hence sturdier bone stmcture. ... [Pg.5468]

Gallium nitrate has been used as an alternative to bisphosphonates in hypercalcemia of malignancy (11), in which it is effective but associated with a higher frequency of renal toxicity (10%) and of nausea and vomiting (14%) than the bisphosphonates. The pathophysiology and treatment of hypercalcemia of malignancy has been reviewed and the role of gallium nitrate considered (12,13). [Pg.1477]

Warrell RP. Jr., Murphy WK, Schulman P, O Dwyer PJ, Heller G. A randomized double-blind study of gallium nitrate compared with etidronate for acute control of cancer-related hypercalcemia. J Clin Oncol 1991 9(8) 1467-75. [Pg.1479]

Although antitumor activity was found for gallium nitrate in pha.se II clinical trials. " its approved use is for the treatment of cancer-related hypercalcemia." It has proved superior to calcitonin and etidronate in this use. The clinical material is the nonahydratc of Ga(NOt)t. [Pg.430]

Gallium nitrate is approved for treating cancer-related hypercalcemia. It showed antitumor activity fur putienb with lymphoma in phase II trials. - Gallium nitrate probably works in hypercalcemia by inhibiting calcium resorption from bone, although the precise mechanism is unknown. Major side effects include hypocalcemia and nephrotoxicity. On continuous infusion, the drug exhibits biphasic elimination with an a half-life of 8.3 to 26 minutes and a half-life of 6.3 to 95 hours. Between 69 and 91% of the dnsc was recovered in the urine. ... [Pg.432]

Gallium nitrate is indicated for the treatment of symptomatic hypercalcemia of mahgnancy not responsive to hydration therapy. However, because of its adverse side-effect profile, it is generally reserved for those who fail to respond to less toxic agents. GaUium... [Pg.954]

Leyland-Jones B. Treatment of cancer-related hypercalcemia the role of gallium nitrate. Semin Oncol 2003 30(2 Suppl 5) 13—19. [Pg.965]

See other pages where Hypercalcemia gallium nitrate is mentioned: [Pg.1485]    [Pg.830]    [Pg.457]    [Pg.165]    [Pg.1023]    [Pg.457]    [Pg.388]    [Pg.777]    [Pg.1427]    [Pg.165]   
See also in sourсe #XX -- [ Pg.954 , Pg.954 , Pg.955 ]



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Gallium nitrate

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