Hyperbaric hyperoxia

Hyperbaric oxygen therapy involves the delivery of 100% oxygen at pressures in excess of normal atmospheric conditions. The intermittent application of hyperbaric hyperoxia is associated with direct and indirect antibacterial effects, angiogenesis in partially ischemic tissue, tissue hyperoxygenation, " vasoconstriction without component hypoxia, and... 

Transgenic mice overexpressing EC-SOD have better neurological outcome and cognitive performance after severe cranial impact [171]. Such animals were, however, more susceptible to hyperbaric oxygen than control animals, an effect ascribed to sparing excessive levels of nitric oxide and thus blocking the normal vasoconstrictive response of the cerebral vasculature to hyperoxia [ 172]. 

Hyperoxia on the Coronary Circulation and Myocardial Functions. Proceedings of the Fifth International Congress on Hyperbaric Medicine, Vol. 2, Simon Frazier University, British Columbia (1974). 

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