Hyperactive bladder

SUR2B/Kir6.2 Efforts have also focused on the development of selective KAXP channel openers for vascular and nonvascular indications including angina, airway hyperactivity, bladder overactivity, and erectile... 

Cisapride can cause functional changes in the urinary tract because of increased pressure in the bladder, which may be a problem in individuals with hyperactive bladders. In individuals who had complete traumatic spinal cord injury, the increase in reflex bladder contractions was sufficient to reduce compliance markedly (23). 

NS-8 and ZD-0947 are calcium sensitive potassium channel openers, that have no effects on the cardiovascular system. They are currently being developed for the treatment of bladder hyperactivity (Phase II) (Figure 8.81). 

KW-7158 is a noncholinergic agent that acts on sensory nerves in the bladder. Phase II trials are under way for incontinence associated with bladder hyperactivity (Figure 8.81). 

Flushing, sweating, pruritus, disorientation, headache, dizziness, hyperactivity convulsions, dyspnea, cough, tachypnea, hiccough, rebound hypoventilation, phlebitis, variations in heart rate, arrhythmias, chest pain, nausea, vomiting, diarrhea, stimulation of urinary bladder with spontaneous voiding. 

Various types of UI may coexist in the same patient. The combination of bladder overactivity and urethral underactivity is termed mixed incontinence. This is often a difficult diagnosis to make because of the often-confusing array of presenting symptoms. Bladder overactivity may also coexist with impaired bladder contractility. This is most common in the elderly and is termed detrusor hyperactivity with impaired contractility. ... 

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