Airway hyperactivity

SUR2B/Kir6.2 Efforts have also focused on the development of selective KAXP channel openers for vascular and nonvascular indications including angina, airway hyperactivity, bladder overactivity, and erectile... 

Cui ZH, Joetham M, Aydintug MK, Hahn YS, et al. 2003. Reversal of allergic airway hyperactivity after long term allergen challenge depends on (gamma) (delta) T cells. Am J Respir Crit Care Med. 168 1324-1332. 

The Navy should be aware that the altered atmospheric conditions on a disabled submarine would affect the toxicity of the gases. For example, cold temperatures will cause crew members to shiver this will increase the rate of respiration because of an increase in metabolic rate. Lower air temperature might also result in the crew s breathing unconditioned air, which is a risk factor for lowerairway disease and airway hyperactivity. However, data are lacking on the precise magnitude of effects therefore, the Navy should conduct research to determine the nature and magnitude of the effects from altered submarine atmospheric conditions. 

RADS is a type of asthma that develops after exposure to a single environmental or occupational exposure to a high concentration of a single chemical or chemical mixture. Though RADS clinically simulates bronchial asthma and is associated with airways hyperactivity, it is different from OA because of its rapid onset following a single exposure, its lack of a sensitization period requirement, and its occurrence without an allergic... 

Klink KJ, Meade BJ. Dermal exposure to 3 amino 5 mercapto 1,2,4 triazole (AMT) induces sensitization and airway hyperactivity in BAFB/c mice. ToxicolSci2003 75(l) 89-98. 

Howell MD, Weissman DN, Meade BJ. Latex sensitization by dermal exposure can lead to airway hyperactivity. Int Arch Allergy Immunol 2002 128(3) 201—11. 

---