HypC protein

HypB protein, 47 289 HypC protein, 47 289 Hyperfine coupling, 13 149-178 anisotropic, 13 150-161 Hyperfine coupling anisotropic dipolar, 13 150-154 nuclear Zeeman interaction, 13 155 quadrupole interaction, 13 154, 155 factors affecting magnitude of metal influence of charge on metal, 13 169-170 isotropic and anisotropic, 13 166-170 libration, 13 170... 

N. Drapal, A. Bock (1998) Interaction of the hydrogenase accessory protein HypC with HycE, the large subunit of Escherichia coli hydrogenase 3 during enzyme maturation. Biochemistry, 37 2941-2948... 

Fig. 6. Schematic representation of the biosynthetic pathway associated with the assembly of the NiFe-hydrogenase catalytic metal center. The precursor to the large subunit is represented by pre-HycE-Fe, and the CO (and/or CN) ligands are provided by the multi-protein complex formed between HypE, HypC and HypD. The source of the ligands to HypE is carbamoyl phosphate, and the insertion reaction is catalyzed by HypF. The Ni atom is inserted into the pre-HycE-Fe-CO-CN-HypC complex in a reaction catalyzed by HypA and HypB. Finally, the Hycl endopeptidase processes the C-terminus of the pre-HycE-Fe-CO-CN-HypC complex, yielding the mature NiFe-hydrogenase large subunit.

Blokesch, M., Albracht, S. P., Matzanke, B. F., Drapal, N. M., Jacobi, A., and Bock, A. 2004. The complex between hydrogenase-maturation proteins HypC and HypD is an intermediate in the supply of cyanide the active site iron of [NiFe]-hydrogenases. J. Mol. Bio. 344, 155-167. 

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