5-hydroxytryptophan antidepressants

Therapautic Function Antidepressant, antiepileptic Chemicel Name 5-Hydroxytryptophan Common Name 5-Hydroxytryptophan Structural Formula ... 

Manier DH, Gillespie DD, Sulser E Dual aminergic regulation of central beta adrenoceptors effect of atypical antidepressants and 5-hydroxytryptophan. Neuropsychopharmacology 2 89-95, 1989... 

Meltzer HY, Lowy M, Robertson A, et al Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders 111. Effect of antidepressants and lithium carbonate. Arch Gen Psychiatry 41 391-397, 1984... 

Serotonin precursors (L-tryptophan. 5-hydroxytryptophan) have some antidepressant action, whereas a reduction in the blood levels of tryptophan in remitted depressed patients can provoke clinical relapse. 

Tryptophan and 5-hydroxytryptophan, the precursors of 5-HT, may have antidepressant effects, alone or in combination with other drugs ( 50). 

MAOIs have the most serious pharmacodynamic interactions of any antidepressant class. As discussed earlier, they can cause a hypertensive crisis and the serotonin syndrome. They potentiate the hypertensive effects of most sympathomimetic amines, as well as tyramine, which is the reason for the avoidance of over-the-counter preparations containing such agents, in addition to the tyramine-free diet ( 508, 509). The serotonin syndrome occurs most often when MAOIs are used in combination with SSRIs and venlafaxine but it can also occur when MAOIs are used with tryptophan, 5-hydroxytryptophan, and some narcotic analgesics. In addition, MAOIs can also significantly potentiate the sedative and respiratory depressant effects of narcotic analgesics. 

Introduction - Concern over the safety of tricyclic antidepressants (TCA)f> has maintained the Impetus to develop new drugs. Compounds reviewed in 1978 Include mianserin,3. nomlfensin, and all non-TCA. S5rm-posia covered dothlepin, mianserin, nomifensin, and trazodone. The uses of L-tryptophan and 5-hydroxytryptophan (5-HTP) in depression and the properties of the new antidepressants " were summarized. The neuropharmacology of depression, and the mechanism of action and pharmacokinetics of antidepressants were reviewed, and the monoamine theory reassessed.20... 

H. M. van Praag and S. de Haan, Depression Vulnerability and 5-Hydrox-ytryptophan Prophylaxis. Psychiatry Research 3 (1980) 75-83 H. M. van Praag, In Search of the Mode of Action of Antidepressants 5-HTP/Tyro-sine Mixtures in Depression. Advances in Bbchemical Psychopharmacobgy 39 (1984) 301-314 H. M. van Praag and R. S. Kahn, L-5-Hydroxytryptophan in Depression and Anxiety. Schweizerische Rundschau fur Medizin Praxis 77, no. 34A (1998) 40-46. 

For pharmaceutical purposes 2000-3000 tonnes of amino acids are required annually worldwide. More than half of this amount ends up in infusion solutions for artificial nutrition. Many amino acid derivatives are pharmacologically important acetylcysteine is mucolytic, (L)-DOPA an active agent to combat Parkinson s disease, and Oxitriptan ((S)-5-hydroxytryptophan) is an antidepressant. Specifically substituted, (D)-configured, a- and /3-amino acids find widespread application as building blocks for drug synthesis. 

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