Hydroxypropyl methylcellulose processability

Iyer et al. [50] investigated the effects of roto-granulation on the performance of hydroxypropyl methylcellulose (HPMC), gelatin, and poly(-vinylpyrrolidone) (Povidone, PVP). In this process, all three binders produced similar results. However, HPMC was preferred due to prolonged drug release profiles, smaller particle size, and better content uniformity. 

For hydroxypropyl methylcellulose acetate succinate, a novel enteric dry coating method has been developed [31]. The unique feature of this method is that the enteric polymer is added in powder form (e.g., mixed with talcum directly to tablets or pellets) whereas a plasticizer diluted with paraffin is sprayed separately. The tablet core temperature is around 40°C, and the film is cured for a short time. To achieve a homogenous film, the rates of powder feeding and plasticizer spray have to be adjusted such that the two processes start and end simultaneously. 

Shah N, Railkar AS, Phuapradit W, Zeng FW, Malick AW. Effect of processing techniques in controlling the relca.se rate and mechanical strength of hydroxypropyl methylcellulose based hydrogel matrices. Eur J Pharm Biopharm 1996 42(3) 183-7. 

Huang Y, Khanvilkar KH, Moure AD, Hilliard-Lott M. Effects of manufacturing process variables on in vitro dissolution characteristics of extended-relca.se tablets formulated with hydroxypropyl methylcellulose. Drug Dev Ind Pharm 2003 29(l) 79-88. 

Mitchell A, Reynolds TD, Dasbach TP. A cpoorly water-soluble drugs using hydroxypropyl methylcellulose, Int J Pharm 2003 250 3-11. Rambali B, Bacrt L. Jans E. Masscart DL. Influence of the roll compactor parameter settings and the compression pressure on the buccal bio-adhesive properties. Int J Pharm 2001 220 129. ... 

To illustrate the method we examine the data of Wehrle, Palmieri, and Stamm (6), who report the optimized production of theophylline pellets by a simple one-step process in a high speed Stephan granulator. The formulation consisted of 20% theophylline drug substance, 30% lactose, and 50% microcrystalline cellulose. It was granulated with a 15% hydroalcoholic solution of hydroxypropyl-methylcellulose. 

Mitchell SA, Reynolds TD, Dasbach TP. A compaction process to enhance dissolution of poorly water-soluble drugs using hydroxypropyl methylcellulose. Int J Pharm 2003 250 3-11. 

Vojdani, E., Torres, J.A., 1989. Potassium sorbate permeability of methylcellulose and hydroxypropyl methylcellulose multi-layer films. Journal of Food Processing and Preservation 13, 417—430. 

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