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Hydroxyphosphine and other oxygen-containing ligands

Carbohydrates are among the most widely available natural products and their use as ligand scaffolding has attracted considerable attention. Once a metal-chelating group is [Pg.191]

Pioneering studies by Selke and Oehme have demonstrated that monosaccharide ligand [Pg.192]

21 has some solubility in water and they reported its use in asymmetric hydrogenation of dehydroamino adds in water. However, without the addition of micelle-forming surfactants, Rh(I) complexes derived from 21 seem to have only limited solubility as well as moderate activity and selectivity. A study of the influence of carbohydrate-derived amphiphiles on the reduction of (Z)-acetamidocinnamic acid in water using [Rh(COD)2 IBF4 - -1BPPM catalyst shows that enantiomeric excesses (ee s) similar to or better than what is observed in MeOH can be obtained. The chiral amphiphile alone gave a small (6%), but reproducible selectivity when used with an achiral Rh catalyst. [Pg.192]

Uemura and RajanBabu groups independently reported the synthesis of Rh(I) complexes of 22 and its catalytic application in asymmetric hydrogenation in water. Synthesis of [Pg.192]

Later improvements addressing both problems of limited solubility and hydrolytic stability came with the development of water-soluble ligands having the notable DuPHOS skeleton, for which excellent enantioselectivity in ketone, olefin and imine reductions have been reported. Zhang and RajanBabu groups independently pursued the synthesis [Pg.192]


See other pages where Hydroxyphosphine and other oxygen-containing ligands is mentioned: [Pg.190]   


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Hydroxyphosphinates

Hydroxyphosphines

Ligand containing

Other Ligands

Other oxygen ligands

Oxygen containing

Oxygen ligands

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