Hydroxyl-substituted water-soluble tertiary phosphines

4 HYDROXYL-SUBSTITUTED WATER-SOLUBLE TERTIARY PHOSPHINES 

It is established by solubility measurements, that a medium sized ligand should have at least two -CH2OH substituents in order to achieve good aqueous solubility [91], However, through the flexible synthesis of these tertiary phosphines the number and the chain length of the hydroxyalkyl substituents built into the target molecule can be varied easily and this way the balance of hydrophilicity and lipophilidty can be finely tuned. Incorporation of other donor atoms, such as S in 109, and a pendant arm with an other reactive substituent (-COOH in 109) makes these compounds even more versatile. 

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