Hydroxyethyl theophyllin

A solution of 100 g of theophylline in 500 ml 1 M solution of KOH was prepared potassium theophylline. To that potassium theophylline was added 120 ml monochlorhydrin ethylene glycol, a mixture was heated at 130°C for 4 hours. The product was dissolved in ethanol and filtered. After crystallization was obtained 7-(2-hydroxyethyl)theophylline. 

FIGURE 7-5. A 0 to 10% gradient separation of polar compounds. Components (1.0 p.g each) (1) uracil, (2) hypoxanthine, (3) 3-methyl xanthine, (4) theobromine, (5) theophylline, and (6) /3-hydroxyethyl theophylline. Solvent A 0.01 M sodium ace-tate/water. Solvent B acetonitrile. Flow rate 2.0 mL/min. Gradient 0-10% solvent B using a linear shape (top line). Run time 50 min. Injection volume 15 p.L. Column Radial-Pak Resolve Cig (10 /xm) 8 mm ID x 10 cm. Detector UV at 254 nm, 0.1 AUFS. (Reproduced from reference 1 with permission.)... 

Proprietary Names. Bio-Phyllin Oxyphylline. 7-(2-Hydroxyethyl)theophylline C9Hi2N403 = 224.2 CAS—519-37-9... 

For the quantitation of theophylline, an internal standard has in most cases been used, e.g. 8-chloro-theophylline, B-hydroxyethyl-theophylline and B-hydroxypropyl-theophyl1ine. 

Sample preparation 100 p,L Sample + 300 p.L 7-(2-hydroxyethyl)theophylline in chloroform isopropanol 50 50, extract. Remove 200 p,L of the organic layer and evaporate it to dryness, reconstitute the residue in mobile phase, inject a 20 p-L iquot. 

Hydroxyethyl)-theophylline Hydroxyethyl-theophylline 7-(2-Hydroxyethyl)-l, 3-dimethylxanthine B.P., Eur. P ... 

Hydroxyethyl-l,3,6,7-tetrahydro-(8//)-imidazo[2,l-/]theophylline 256 was prepared by condensation of 7/3-bromoethyl-8-bromotheophylline 255 with 2-aminoethanol (Equation 112) <1999EJM1085>. Based on this strategy, a rapid access to 6,7-dihydro-l/f-thiazolo [2,3-/]purine-2,4-diones 258 was also described as in Equation (113) <1996PCJ194>. 

THEOPHYLLINE, 8-BENZYL-7-(2- (ETHYL (2-HYDROXYETHYL) AMINO) ETHYL) -.HYDROCHLORIDE... 

Water dispersible microspheres containing 5-FU or theophylline units release pharmaceutically active molecules as well as water soluble ones. Figure 7 shows how hydroxyethyl-5-FU and hydroxyethyltheophylline release by ester hydrolysis of graft copolymers in aqueous dispersion solution by comparing that of the water soluble copolymers in homogeneous aqueous solution. As shown in the figure, the hydrolysis depends on the chemical structure of polymeric... 

Poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) Theophylline, triamterene, oxprenolol, buflomedil, vitamin B12, inulin, myoglobin [105]... 

Xanthinol Niacinate. 3-Pyridlnecarboxylic acid compd with 3,7-dihydra-7-[2-hydroxy-3-[(2-hydroxyethyl)-methyIamino)propyl l,3-dimethyl-IH-purine-2,6-diorte (f J) 7-[2-hydrOxy-3-[(2-hydrOxyethyI)methylamino]prop-yljtheophyliine, compd with nicotinic acid 7-[3-[N-(2-hydr-oxyethyl)amino]-2-hydrOxypropyl)theophylline nicotinate xanthinol nicotinate SK 331 A Angiomin Complamex Complamin Sadamin Xavin. mol wt 434-45. 

The diffusion behaviour of low molec.wt. drugs (theophylline, proxyphylline and oxprenolol.HCl) from pH-sensitive, anionic, initially glassy copolymer networks of 2-hydroxyethyl methacrylate with acrylic acid and/or methacrylic acid was studied as a function of pH, ionic strength and the nature of the dissolution medium. The dissolution media used were simulated physiological fluids such as simulated gastric fluid, a phosphate buffer of pH 7.4 and a glutarate buffer solution of pH 7.19 refs. USA... 

Dry theophylline heated with ethylene carbonate at 220-225° until gaseous evolution ceases l,3-dimethyl-7-(y -hydroxyethyl)xanthine. Y 75-80%. F. e., also with propylene carbonate, s. L. Fabbrini and R. Gencioni, Farmaco, Ed. sci. 17, 660 (1962). 

Furthermore, chitosan-GSH-coated poly(hydroxyethyl methacrylate) nanoparticles prepared by radical polymerization showed an improvement in mucoadhesion and in the apparent permeability coefficient (Papp) compared to unmodified chitosan [70]. Finally, thiolated chitosan nanoparticles significantly enhanced the antiinflammatory effect of theophylline, as evidenced by the decrease in parameters such as eosinophilis in bronchoalveolar lavege fluid and bronchial damage [71]. 

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