Hydroxyapatite thick films

Figure 4.4 Design and fabrication of the osteophilic multilayer architecture. Components of the film (a) Chitosan (75-85% deacetylated chitin) a polycation (b) Poly(acrylic acid) (PAA) (c) A hydrolytically degradable poly(p-amino ester) (Poly2), a polycation and (d) osteoinductive recombinant human bone morphogenetic protein 2 (rhBMP-2) (e) Schematic of the modular electrostatic assembly. Osteoconductive hydroxyapatite (HAP) is complexed with chitosan and incorporated into nanoscale thick films along with poly(acrylic acid) in a bilayer architecture. A hydrolytically degradable poly(P-amino ester)-based multilayer fihn incorporating osteoinductive rhBMP-2 lays atop the osteoconductive layer, (f)...

Dental implants and prosthetics alone account for a substantial proportion of the dental industry. It is therefore of no surprise that researchers focus heavily on this avenue. In contrast to other industries, dental industry nanocoatings do not perpetually involve the deposition of thin nanolayers onto a substrate. Often they can refer to the incorporation of nanostructured materials or particles into coatings on contact surfaces. For instance, a recent piece of work examined the usage of nanostructured hydroxyapatite (HA) as a filler material for root canal. HA (a commonly used material in coating implants to aid cell proliferation) particles sized at approximately 26 mn were incorporated into root canal sealer at variable ratios. At high concentrations, there was little difference in film thickness (implying they would meet ISO standards for root canal sealers). The observed improvements suggested that nanostructured HA could be used to formulate more stable tooth material interfaces [40]. 

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