6- Hydroxy-1 - -2-trifluormethyl

Hydroxy- -trifluormethyl-ethanphosphonsaure (66°/ als Anilin-Salz) Schmp. 190-195° (Zers.). 

A second potential reaction path (C(2), TS(e ), Fig. 15) for twofold HFIP activation was calculated, which differs from TS(e ) with regard to the hydrogen bond from H O to HFIP. Here, a fluorine atom of the trifluormethyl group serves as hydrogen bond acceptor, and not a second hydroxy function. Both transition states are similar in energy but the corresponding precomplex C(2), consisting of H O and two HFIP molecules, lies 18.4 kJ moF above C(2). 

Mit Lithiumalanat werden 5-Ethoxycarbonyl-2,4-difluor-l-(methoxy-methyl)-imidazol zu 4-Fluor-4-hydroxy methyl-1-(methoxy-methyl)-imidazol499 und l-(2,6-Dimethyl-phenyl)-5-fluor-2-phenyl-4-trifluormethyl-imidazol zu l-( 2,6-Dimethyl-pheny )-2-phenyl-4-trifluormethyl-imid-azol927 reduziert. 

R - H 2-[2-(5-Hydroxy-2,3-dithiapentyl)-4-methoxy-l-pyridiniono -5-trifluormethyl-benzimidazolinid, 32% Schmp, 139,5° (Zers.)... 

Hydroxy-5-trifluormethyl-l,3,4-oxadiazole reagieren mit substituierten 3-Amino-2H-aziri-nen unter dipolarer Addition zu 2-Oxo-2H-imidazolium-trifluoracetamidat und 3-Oxo-2,3,4,5-tetrahydro-1,2,4-triazin773 774. 

Dimethylphosphinsaure-(2-hydroxy-3,3,3-trifluor-1,1,2-tris-[trifluormethyl]-propylester)... 

Dipipcridino-phenyl- E2, 482 Di-2-propinyloxy-ethyl- E2, 196 Dipropyl-(4-methoxy-N-lfaethyl-amlino)- E2, 296 Dipropyl-propyloxy- E2, 212 Divinyl-phenyl- E2 874 Ethoxy-ethyl-methoxycarbonylmethyl- E2, 21 Ethoxy-ethyl-phenyl- E2, 23 Ethoxy-hydroxy-methyl- E2, 130, 131 Ethoxy-hydroxy-phenyl- E2, 131, 185, 187, 190, 422 Ethoxy-(2-propinyloxy)-trifluormethyl- E2, 196 Ethyl-ethylthio-(l-methyl-3-oxo-butyl)- E2, 223 Ethyl-methyl-phenyl- -tosylimid E2, 11.3 Ethyl-pbenyl-propyloxy- E2, 281 F.thyl-phenyl-propylthio- E2, 225. Hydroxy-(2-isopropyl-5-methvl-cyclohexvloxv)-methyl- E2, 392... 

Hydroxy- l-trifluormethyl-ethan- E2, 308 l-Hydroxy-2,2,2-trifluor- l-trifluormethyl-ethan- -dibutylester E2, 358... 

Hydro-(4-methyl-phcnyl)-trifluor- E2, 837 Hydro-methyl-trifluor- E2, 836 Flydro-organo-trifluor- E2, 835 Hydro-phenyl-trifluor- E2, 837 Hydro-trifluor-trifluormethyl- E2, 837 Hydroxy-methyl-triphenyl- XII/1, 106 Hydroxy-tetrabenzyl- XII/1, 106 Hydroxy-tetraethyl- XII/1, 106 Isopropyloxy-methyl-triphenyl- E2, 884 Isopropyl-tetrachlor- E2, 430 Methoxy-methyl-triphenyl-... 

Malonsaure (1-Hydroxy-2,2,2-trifluor-1 -trifluormethyl-ethyl)- -dinitril E5, 1510 [Keton + H2C(CN)2]... 

Harnstoff t,3-Bis-[t-hydroxy-2,2,2-trifluor-l-trifluormethyl-ethyl]-E14a/2, 62 (Keton/Harnstofl)... 

Butin l-Ethoxy-3-hydroxy-4,4,4-trifluor-3-trifluormethyl- E15/3, 3208 (H - MgBr - CR2-OH)... 

Phenol 2-(l-Hydroxy-2,2,2-tri-fluor-l-trifluormethyl-ethyl)-4-methyi- VI/lc, 1035... 

Carbamidsanre N-(l-Hydroxy-2,2,2-trifluor-ethyl)- -(4-methoxy-benzylester) E14a/2, 60 (R-CHO/RO-CO-NH2) Pyrrol 4-Acetyl-2-ethoxycarbonyl-5-methyl-3-trifluormethyl-E6a, 625 (F3C-CO-CH2-COOR + HN02 2,4-Pentandion/Zn)... 

Oxazol 2-tert.-Butyl-4-(3-hydroxy-propyl)-5-trifluormethyl- E8a, 928 [(F3C-C0)20 + 2-COO H —... 

Oxazolidin 2,2-Bis-[trifluormethyl]-4-(4-hydroxy-benzyl)-5-oxo- El4a/2, 644 (H2N-C-COOH + Keton)... 

For the determination of the absolute stereochemistry by NMR spectroscopy, Mosher derivatives are widely used [25]. This method is based on the formation of (R)/(S)-MTPA (a-methoxy-a-(trifluormethyl)phenylacetic acid) esters and comparison of the NMR data of both diastereomers. However, it is limited to compounds with amenable functional groups to be derivatized (typically hydroxy groups) and in some cases the conclusions from the NMR experiments are unsafe. 

Zur Bildung von 4-(4-Methyl-phenyl)-5-trifluormethyl-l,3-thiazol(70%) aus dem 5-Hydroxy-2,5-dihydro-Dcrivat mit Tctraphosphordecasulfid in Benzol s. Lit.1880. 

Die Methode ist zur Synthese von l-Aryl-4-hydroxy-3-trifluormethyl-lH-pyrazolen geeignet2440. 

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