2-Hydroxy-3- propenoic acids

Acidic and basic hydrolysis of ethyl 4-oxo-4//-pyrido[l, 2-u]pyrimidin-3-carboxylates gave 3-carboxylic acid derivatives (OlMIPl). Stirring rerr-butyl ( )-3-(2-hydroxy-8-[2-(4-isopropyl-l, 3-thiazol-2-yl)-l-ethenyl]-4-oxo-4//-pyrido[l,2-u]pyrimidin-3-yl)-2-propenoate in CF3CO2H at room temperature yielded ( )-3-substituted 2-propenoic acid. 

C 2HijF,N202 90357-51-0) see Bicalutamide 4 -cyano-3 -trifIuoromethylmethacrylanilide (CijHijFjNjO 90357-53-2) see Bicalutamide Af-[4-cyano-2-(trifluoromethyl)phenyl]acetamide (C (,H7F,N20 175277-96-0) see Mabuterol /V-(4-cyano-3-trifluoromethylphenyl)-3-(fluorophenyl-sulfanyl)-2-hydroxy-2-methylpropionamide (C,hH,4F4N202S 90356-78-8) see Bicalutamide 2-cyano-3-(3,4,5-trimethoxyphenyl)-2-propenoic acid ethyl ester... 

C24H33FO4 1251-27-0) see Fluocortolone 2-fluoro-3-hydroxy-2-propenoic acid ethyl ester (C5H7FO3 185692-96-0) see Fluorouracil... 

Ci,H 20 122-97-4) see Fomocaine Phenprobamate 3-phenyl-2-propenoic acid (C,jHh02 621-82-9) see Docetaxel [2alf-(2aa,4p,4aP,6 3,9a,lla,12a,12aa,12ba)]-3-phenyl-2-propenoic acid 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a, 5,6,9,10,ll,12,12a,12b-dodecahydro-ll-hydroxy-4a,8, 13,13-tetramethyl-S-oxo-4,6-bis[[(2,2,2-trichloroethoxy)-carbonyl]oxy]-7,ll-niethano-l/f-cyclodeca[3,4]benz[l,2-A] oxet-9-yl ester... 

Methyl 3-hydroxy-2-methylenebutanoate Butyric acid, 3-hydroxy-2-methylene-, methyl ester (8) Butanoic acid, 3-hydroxy-2-methylene-, methyl ester (9) (18020-65-0) Methyl acrylate Acrylic acid, methyl ester (8) 2-Propenoic acid, methyl ester (9) (96-33-3)... 

Other suitable alternate aromatic carboxylic substrates include 3-chlorobenzoic acid, 4-chlorobenzoic and 3-(4-hydroxy-3-methoxyphenyl)-propenoic acid. 

Methyl diformyl acetate 2-Propenoic acid, 2-formyl-3-hydroxy-, methyl ester (9) (39947-70-1)... 

Hydroxy-2-phenylethanoic acid Propenoic acid (Z)-9-Octadecenoic acid... 

SYNS ACRYLIC ACID-2-HYDROXYPROPYL ESTER P-HYDROXYPROPYL ACRYLATE 1,2-PROPANEDIOL-1-ACRYLATE 2-PROPENOIC ACID-2-HYDROXY-PROPYL ESTER PROPYLENE GLYCOL MONOACRYLATE... 

Halocyclization of the amide 5 (R1 = C6H5 R2 = H R3 = CH3), derived from (S)-proline and ( )-2-methyl-3-phenyI-2-propenoic acid, can be performed by stirring a mixture of the potassium salt of 5 and 2 equivalents of TV-bromosuccinimide in dimethylformamide for 48 hours. This results in a 99 1 (transjeis) mixture of lactones 6 in 91 % yield1. Debromination of the crude lactone, followed by acidic hydrolysis, gives ( + )-(/ )-2-hydroxy-2-methyl-3-phenylpropanoic acid fmp 115-117 °C [a]D + 16.7 (c = 5.71, dioxane)3] in 36% overall yield. Other bromolactones 6 can be similarly prepared from the corresponding (S)-7V-(a,/l-unsaturated acyl)prolines 5. 

We have just spoken of the different action of the alpha-, beta-, and gowwo-halogen acids toward alkalies (p. 233), and of the similar different action of the alpha-, beta-, and gamma-hydioxy acids when dehydrated (p. 241). The second of the above acids, viz., the /3-hydroxy propionic acid, shows the reaction characteristic of eto-acids. On heating, or by the action of sulphuric acid, it loses water and is converted into the corresponding ethylene unsaturated acid, propenoic acid, as follows ... 

Propenoic acid is commonly known as acrylic acid (p. 172), and j(3-hydroxy propionic acid is therefore named hydracrylic acid, i.e., hydrated acrylic acid. 

The loss of water from hydroxy acids and the formation of unsaturated acids has been met with before in connection with heta-hydroxy mono-basic acids e.g., hydraciylic acid, jS-hydroxy propionic acid, and its conversion into acrylic acid, propenoic acid (p. 172). In such cases the beta-hydioxy acid loses water from two neighboring carbon groups thereby creating a double bond. 

H.87) 2-Propenoic acid, (4-hydroxy-3-methoxyphenyl)-, 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, 4-hydroxy-3-methoxycinnamic acid, ferulic acid (1135-24-6] ( )- (537-98-4] (Z)- (1014-83-1]... 

H.88) 2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-, 3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid, 3-hydroxy-4-methoxycinnamic acid, isoferulic acid (537-73-5] ( )- 125522-33-2] (Z)- (1135-16-6]... 

The fourth part of this review concerns the development of the previously described intramolecular cyclisation of 2-methoxyphenyl acetones and 2-hydroxy-3-(2-methoxyphenyl)propenoic acids leading to 2-substituted benzofurans [17, 38]. 

The amide of bis(2-thienyl)glycolic acid with 2-(lV-pyrrolidyl)ethyl-methylamine and its methyl quaternary ammonium hydroxide showed spasmolytic activity in mice.155 Esters of 3,3-bis(2-thienyl)propenoic acid and 2-ferf-aminoethanols 99 (X = OCH2CH2NR2) were obtained both by dehydration of the hydroxy ester 100 (X = OCH2CH2NR2)156 and by esterification of unsaturated acid 99 (X = OH).157 These amino esters showed analgesic, antispasmodic, and antitussive activity. Amides 99 (X = NHAr) were synthesized by reaction of the appropriate primary aromatic... 

Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, monoester with 3-(4-hydroxy-3-methoxyphenyi)-2-propenoic acid, (1a,3a,4a,5p)- 4249 ... 

Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester ferulic acid, methyl ester 3712 ... 

Propenoic acid, 3-hydroxy-4-methoxy-phenyl)-, trans- ferulic acid ... 

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