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9-Hydroxy-2-methyl-477-pyrido alkylation

Treatment of alkyl 9-benzyloxycarbonyl-3-methyl-6-oxo-2/7,6//-pyr-ido[2,l-f ][l,3]thiazine-4-carboxylates with BBr3 in CH2CI2 at -70 °C for 0.5-1 h and at room temperature for 3h yielded 9-carboxyl derivatives. The decarboxylation of these acids was unsuccessful. Hydrolysis of diethyl cA-3,4-H-3,4-dihydro-3-methyl-6-oxo-2//,6//-pyrido[2,l-f ][l,3]thiazine-4,9-dicarboxylate in aqueous EtOH with KOH at room temperature for 3 days yielded 4-ethoxycarbonyl-3,4-dihydro-3-methyl-6-oxo-2//,6//-pyrido-[2,l-f ] [1,3]thiazine-9-carboxylic acid (00JCS(P1)4373). Alkyl 9-hydroxy-methyl-3-methyl-6-oxo-3,4-dihydro-2//,6//-pyrido[2,l-f ][l,3]thiazine-4-car-boxylates were O-acylated with AC2O and (PhC0)20 in pyridine at room temperature for 12-48h. [Pg.192]

Cyclocondensation of pipecolinic acid and malic acid anhydride in pyridine afforded 3-hydroxy-2,3-dimethylperhydropyrido[l,2-a]pyrazine-l, 4-dione (74CB2804). Cyclocondensation of bis(2,4,6-trichlorophenyl) mal-onates with 2-methyl-, 2-benzyl- and 2-ethoxycarbonylmethylquinoxalines and -3-ones at 250°C afforded 8-hydroxy-10//-pyrido[l,2-a]quinoxalin-10-ones and their 5,6-dihydro-6,10-dione derivatives (77M103). Under Horner-Wittig reaction conditions, the reactions of 2-formylquinoxaline and dialkyl phosphonosuccinates (314) also involved cyclization to give alkyl 10-oxo-10//-pyrido[l,2-a]quinoxahne-8-carboxylate (80LA542). [Pg.249]

The side chain hydroxy group of 3-(2-hydroxyethyl)-2-methyl-9-methoxy-4//-pyrido[l,2-u]pyrimidin-4-one, and that of its 6,7,8,9-tetrahydro derivative was acylated with MeS02Cl in the presence of NEts in CH2CI2 at room temperature (95MIP4, 96MIP2). The hydroxy group of 2-[4-(4-hydro-xybenzoyl)benzyloxy]-3-methyl-4//-pyrido[l, 2-u]-pyrimidin-4-one, its 6-methyl derivative and 2-[4-(4-hydroxybenzoyl)benzylthio]-3-methyl-4//-pyrido[l, 2-u]pyrimidin-4-one was alkylated with 4-(2-chloroethyl)morpholine hydrochloride and 4-picolyl chloride hydrochloride (96EUP733633). [Pg.213]

The octanol-water (pH 5) partition coefficients of alkyl-substituted 4H-pyrido[l,2-a]pyrimidines-4-ones 10 and 11, 3-phenyl and 3-ester derivatives (R2 = Ph, COOEt), and some tetra- and hexahydro derivatives were determined by the classical shake-flask technique at ambient temperature (81MI4 82MI9). Hansch-type 7r values of the substituent (R-R2) were also calculated. The apparent octanol-water partition coefficients of seg-anserine 6 and its 7-methyl derivative were measured (88MI14). The pAa values and apparent octanol-water partition coefficients (at pH 7.4) of risperidone 7 (92MI20, 92MI30), its 9-hydroxy derivative (92MI30), and ocaperidone 8 were reported (92MI20). [Pg.107]

The quaternary salt 366 was not obtained from 9-hydroxyl-2-methyl-4 -pyrido[ 1,2-a]pyrimidin-4-one 365 and benzyl chloride by heating in nitromethane (92KGS1660). The hydroxy group of 9-hydroxylpyridopy-rimidin-4-one 365 was alkylated with methyl iodide in dimethyl sulfoxide at 40°C for 30 hours to give 9-methoxy derivative 367 in 9% yield. [Pg.183]


See other pages where 9-Hydroxy-2-methyl-477-pyrido alkylation is mentioned: [Pg.175]    [Pg.188]    [Pg.192]    [Pg.512]    [Pg.211]    [Pg.211]    [Pg.213]    [Pg.126]    [Pg.128]    [Pg.133]    [Pg.134]    [Pg.169]    [Pg.172]    [Pg.175]    [Pg.176]    [Pg.178]    [Pg.188]    [Pg.191]    [Pg.194]    [Pg.103]    [Pg.104]    [Pg.22]    [Pg.211]    [Pg.213]    [Pg.213]    [Pg.192]    [Pg.245]    [Pg.570]    [Pg.211]    [Pg.211]    [Pg.213]    [Pg.363]    [Pg.211]    [Pg.211]    [Pg.213]    [Pg.213]   
See also in sourсe #XX -- [ Pg.85 , Pg.213 ]




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1- Alkyl-2-hydroxy

2- Hydroxy-3-methyl-4//-pyrido

3- -2-hydroxy-4//-pyrido

Alkyl-methyl

Hydroxy alkylation

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