Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

4-Hydroxy-3-methoxymandelic acid

Disulfoton exposure altered catecholamine levels in animals, and this hormonal imbalance may be associated with elevated acetylcholine levels (Brzezinski 1969, 1972, 1973 Brzezinski and Ludwicki 1973 Brzezinski and Rusiecki 1970 Wysocka-Paruszewska 1970, 1971). In these studies, acute dosing with disulfoton caused increases in urinary and plasma noradrenaline and adrenaline levels, accompanied by decreases of adrenaline in the adrenal glands, in rats. In addition, the major urinary metabolite of catecholamine metabolism, 4-hydroxy-3-methoxymandelic acid (HMMA), was recovered in the urine from rats given acute doses of disulfoton (Wysocka-Paruszewska 1970,... [Pg.73]

Wysocka-Paruszewska B. 1970. Urine level of 4-hydroxy-3-methoxymandelic acid in urine of rats poisoned with phosphorus organic insecticides. Dissertationes Pharmaceuticae et Pharmacologicae 22 485-489. [Pg.199]

Disposition in the Body. Rapidly metabolised before reaching the systemic circulation and therefore ineffective after oral administration poorly absorbed after subcutaneous injection widely distributed throughout the body. The principal metabolic reaction is 0-methylation catalysed by catechol-O-methyltrans-ferase to form normetanephrine this is followed by oxidative deamination catalysed by monoamine oxidase, to form 4-hydroxy-3-methoxymandelic aldehyde which is converted to 4-hydroxy-3-methoxymandelic acid (vanillylmandelic acid) and to... [Pg.820]

Vanillin may also be prepared synthetically by condensation, in weak alkali, of a slight excess of guaiacol with glyoxylic acid at room temperature. The resultant alkaline solution, containing 4-hydroxy-3-methoxymandelic acid is oxidized in air, in the presence of a catalyst, and vanillin is obtained by acidification and simultaneous decarboxylation. Vanillin is then purified by successive recrystallizations. [Pg.799]

To conclude, it is interesting to discuss in more detail the synthesis of vanillin from 4-hydroxy-3-methoxymandelic acid. According to scheme 1, glyoxylic acid reacts with guaiacol to give the substituted mandelic acid. [Pg.524]

Gas Chromatographic Estimation of Urinary Homovanillic Acid and 4-Hydroxy-3-methoxymandelic Acid Using Capillary Columns Clin. Chim. Acta 55(1) 111-112 (1974)... [Pg.94]

Gas Chromatography in the Estimation of Urinary Metanephrines and VMA [4-Hydroxy-3-methoxymandelic Acid] Clin. Chim. Acta 32(3) 361-366 (1971) CA 75 45492b... [Pg.259]

McGregor, R. F., Khan, M., Marrack, D. and Sullivan, M., Quantitative analysis of 4-hydroxy-3-methoxymandelic acid by direct photometric scanning of urinary extracts separated by thin-layer chromatography. Am. J. Clin. Pathol. 46, 163 (1966). [Pg.193]

The diagnosis of neural tumours such as phaeochromocytoma and neuroblastoma is heavily dependent on the laboratory measurement of urinary levels of methylated catecholamines and of their two acidic catabolites, 4-hydroxy-3-methoxymandelic acid (VMA) and 4-hydroxy-3-methoxyphenyl acetic acid (HVA). [Pg.63]

The major metabolites resulting from these processes are the methylated derivatives metadrenaline and normetadrenaline, and 4-hydroxy, 3-methoxymandelic acid, (HMMA, VMA). [Pg.72]

See also adrenaline, 4-hydroxy, 3-methoxymandelic acid, phaeochromacytoma... [Pg.72]

HYDROXY, 3-METHOXYMANDELIC ACID (HMMA) (VANILLYL-MANDELIC ACID, VMA)... [Pg.187]

See other pages where 4-Hydroxy-3-methoxymandelic acid is mentioned: [Pg.125]    [Pg.135]    [Pg.356]    [Pg.322]    [Pg.820]    [Pg.127]    [Pg.13]    [Pg.2]    [Pg.142]    [Pg.1561]    [Pg.798]    [Pg.656]    [Pg.194]    [Pg.10]    [Pg.72]    [Pg.187]    [Pg.368]    [Pg.373]    [Pg.656]    [Pg.277]    [Pg.277]   
See also in sourсe #XX -- [ Pg.571 ]



SEARCH



4- hydroxy-3-methoxymandelate

4-Methoxymandelic acid

© 2024 chempedia.info