Hydroxy acid macromers

Sawhney and co-workers prepared a series of PEC-co-poly(a-hydroxy acid) diacrylate macromers and investigated their photopolymerization into crosslinked bioerodible hydrogels. Certain types of these hydrogels were evaluated for use in preventing postsurgical adhesion and vascular restenosis. ... 

Sawhney, A. S., Pathlak, C. P. and Hubbel, J. A., Bioerodible hydrogels based on photo-polymerized PEG-co-poly(x-hydroxy acid) diacrylate macromers. Macromolecules, 26, 581, 1993. 

A.S. Sawhney, C.P. Pathak, J.A. Hubbell, Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers. Macromolecules 26 (1993) 581-587, doi 10.1021/ma00056a005. 

Sawhney, A.S., Pathak, C.P., and Hubell, J.A., 1993, Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poIy(a-hydroxy acid) Diacrylate Macromers. Macromolecules, 26 581... 

The study of acid-base interaction is an important branch of interfacial science. These interactions are widely exploited in several practical applications such as adhesion and adsorption processes. Most of the current studies in this area are based on calorimetric studies or wetting measurements or peel test measurements. While these studies have been instrumental in the understanding of these interfacial interactions, to a certain extent the interpretation of the results of these studies has been largely empirical. The recent advances in the theory and experiments of contact mechanics could be potentially employed to better understand and measure the molecular level acid-base interactions. One of the following two experimental procedures could be utilized (1) Polymers with different levels of acidic and basic chemical constitution can be coated on to elastomeric caps, as described in Section 4.2.1, and the adhesion between these layers can be measured using the JKR technique and Eqs. 11 or 30 as appropriate. For example, poly(p-amino styrene) and poly(p-hydroxy carbonyl styrene) can be coated on to PDMS-ox, and be used as acidic and basic surfaces, respectively, to study the acid-base interactions. (2) Another approach is to graft acidic or basic macromers onto a weakly crosslinked polyisoprene or polybutadiene elastomeric networks, and use these elastomeric networks in the JKR studies as described in Section 4.2.1. 

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