Hydroxy acid dehydrogenase

Fig. 8a, b. a Biosynthetic pathways for the major aliphatic components of suberin. b Representation of the active site of co-hydroxy acid dehydrogenase involved in the synthesis of the dicarboxylic acids characteristic of suberin. From [74]... 

DIHYDROOROTATE OXIDASE DIMETHYLANILINE MONOOXYCENASE FERREDOXIN NADP REDUCTASE GLUTATHIONE REDUCTASE 0-2-HYDROXY ACID DEHYDROGENASE... 

ACID-BASE RELATIONSHIPS OXYGEN, OXIDES 0X0 ANIONS d-2-HYDROXY-ACID DEHYDROGENASE (S)-2-HYDROXY-ACID OXIDASE 3-HYDROXYACYL-CoA DEHYDROGENASE /3-HYDROXYACYL THIOESTER (or, ACP) DE-HYDRASE... 

A limited quantity of D-lactate is converted to pyruvate by a mitochondrial flavoprotein enzyme D-2-hydroxy acid dehydrogenase. Thus, the development of D-lactate acidosis requires excessive production of D-lactate and an impairment in its metabolism. The clinical manifestations of D-lactic acidosis are characterized by episodes of encephalopathy after ingestion of foods containing carbohydrates. 

More detailed accounts of particular enzyme reactions in the metabolism of ascorbic acid have appeared (K. Suzuki, Y. Mano, and N. Shimazono, Enzymatic formation of L-gulonolactone from n-glucuronolactone by rat liver microsomes. J. Biochem. (Tokyo) 47, 846-849, 1960 K. Suzuki, Y. Mano, and N. Shimazono, Conversion of L-gulonolactone to L-ascorbic acid. Properties of the microsomal enzyme in rat liver. J. Biochem. (Tokyo) 48, 313-315, 1960 J. D. Smiley, and G. Ashwell, Purification and properties of fi-L-hydroxy acid dehydrogenase. II. Isolation of fi-keto-L-gulonic acid, an intermediate in L-xyliJose biosynthesis. J. Biol. Chem. 236, 357-364, 1961). 

Fig. 18. Proposed structure of the active site of

Transfer of a hydride between substrate and coenzyme and proton relay in active site of an NADH-dependent D-2-hydroxy acid dehydrogenase. 

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