4-hydroxy-2H-l-benzopyran-2-one

Coum rinic Acid Compounds. These synthetic phyUoquinone derivatives and congeners have been employed as anticoagulants since the isolation of 3,3 -methylenebis(4-hydroxy-2H-l-benzopyran-2-one) [66-76-2] (bis-4-hydroxycoumarin or dicoumarol) (1) from spoiled sweet clover in 1939. The ingestion of the latter was responsible for widespread and extensive death of bovine animals at that time. The parent compound for the synthesis of many congeners is 4-hydrocoumarin, which is synthesized from methyl salicylate by acetylation and internal cyclization. The basic stmctures of these compounds are shown in Figure 2, and their properties Hsted in Table 6 (see Coumarin). 

Chemical Name 3-[3-(4-Chlorophenyl)-l-(5-chloro-2-thienyl)-3-hydroxypropyl]-4-hydroxy-2H-l-benzopyran-2-one... 

A mixture of methyl 2-methyl-4-oxo-4H-l-benzopyran-3-carboxylate and 1 N NaOH heated on a steam bath for 5 min. or until a soln. results -> 3-acetyl-4-hydroxy-2H-l-benzopyran-2-one. Y 86%. F. e., also imines with coned. NH4OH, and limitations s. S. Klutdiko, J. Shavel, Jr., and M. von Strandtmann, I. Org. Chem. 39, 2436 (1974). 

S Synonyms. 7-Hydroxy-4-methyl-2H-l-benzopyran-2-one Hymecromone Imecromone 7-Hydroxy-4-methyl-2-oxo-3-chromene 4-Methylumbelliferone P-Methylum-belliferone ... 

Di-Me ether 3-Hydroxy-6,7-dimethoxy-4-phenyl-2H-l -benzopyran- 2-one. 3-Hydroxy-6,7-dimethoxy-4-phenylcoumarin Ci7H,405 M 298.295... 

Other Names Coumarin, 7-hydroxy-4-methyl- Umbelliferone, 4-methyl- P-Methylumbelliferone 4-MU 4-Methyl-7-hydroxycoumarin 4-MethylumbelUferone 7-Hydroxy-4-methyl-2-chrome-none 7-Hydroxy-4-methyl-2-oxo-3-chromene 7-Hydroxy-4-methyl-2H-l-benzopyran-2-one 7-Hydroxy-4-methyl-2H-chromen-2-one 7-Hydroxy-4-melhylcoumarin BilcoUc Bilicante Bili-ton H Cantabilin Cantabiline Cholestil Cholonerton Cholspasmin Coumarin 4 Coumarin 456 Cumarote C Eurogale Himecol Hymecromone Imecromone LM 94 Medilla Mendiaxon NSC 19026 NSC 9408 Omega 127 Pilot 447 CA Index Name 2H-l-Benzopyran-2-one, 7-hydroxy-4-methyl-CAS Registry Number 90-33-5 Merck Index Number 4854 Chemical Structure... 

Hydroxy-8-methyl-4-phenyl-6-propionylcoumarin. 7-Hydroxy-8-methyl-6-(l-oxopropyl)-4-phenyl-2H-l-benzopyran-2-one, 2008... 

SYNS 3-(o-ACETONYLBENZYL)-4-HYDROXY-COUMARIN SODIUM SALT ATHROMBIN COUMADIN SODIUM 4-HYDROXY-3-(3-OXO-l-PHENYLBUTYL)-2H-l-BENZOPYRAN-2-ONE SODIUM SALT (9CI) MAREVAN (SODIUM SALT) ... 

Dihydroxy-3- 3-methyl-2-butenyl)phenyI -7-hydroxy-5-methoxy-2H-l-benzopyran-2-one, 9C1. 3- 2,4-Dihydroxy-3-prenylphenyl)-7-hydroxy-5-methoxycoumarin [155023-53-3]... 

Hydroxy-4- 4-hydroxypheny[)-6- 3-methyl-2-buteny[)-2H-l-benzopyran 2-one, 9CI. Inflacoumarin A [158446-33-4]... 

CA Index Name 2H-l-Benzopyran-2-one, 4-heptadecyl-7-hydroxy-CAS Registry Number 26038-83-5 Merck Index Number Not listed Chemical Structure... 

CA name as indexed 2H-l-benzopyran-2-one, 4-hydroxy-Common names dicoumarol, dicoumarin CA number [66-76-2]... 

Ethyl-7-hydroxy-4-methyl-8-(l-oxopropyl)-2H-l-benzopyran-2-one, 2005 1 -(1 -Hydroxy-4,8-dimethoxy-2-naphthalenyl)-1 -propanone, 1978... 

Fluoro-2-hydroxyphenyl)-2-methyl-1 -propanone, 2014 l-(3-Fluoro-4-hydroxyphenyl)-2-methyl-l-propanone, 2014 l-(3-Fluoro-4-methoxyphenyl)-2-methyl-l-propanone, 2023 l-(3-Fluoro-2-hydroxyphenyl)-l-propanone, 1754 1 -(3 -Fluoro-2-methoxyphenyl)-1 -propanone, 1793 4-(l-Acetoxypropyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-8-(2-methyl-l-oxopropyl)-2H-l-benzopyran-2-one (-), 2080 l,l -[Oxybis(4-hydroxy-3,l-phenylene)]bis-l-propanone, 2118... 

Bromo-7-hydroxy-4-methyl-8-propionylcoumarin. 6-Bromo-7-hydroxy-4-methyl-8-( 1 -oxopropyl )-2H-l -benzopyran-2-one, 1997 BromonligmosinB. 2-[[3-Bromo-5,7-dihydroxy-2,2-dimethyl-8-(2-methyl-l-oxopropyl)-2H-l-benzopyran-6-yl]methyl]-3,5-dihydroxy-4,4-dimethyl-6-(2-methyl-l-oxopropyl)-2,5-cyclohexadien-l-one, 2152... 

Chloro-7-hydroxy-4-methyl-8-propionylcoumarin. 6-Chloro-7-hydroxy-4-methyl-8-(l-oxopropyl)-2H-l-benzopyran-2-one, 1753,1998 Conglomerone. 2-Methyl-l-(2,4,6-trimethoxyphenyl)-l-propanone, 2043 Crocatone. l-(7-Methoxy-l,3-benzodioxol-5-yl)-l-propanone, 1992 Dehydrodipropioguaiacone. l,l -(6,6 -Dihydroxy-5,5 -dimethoxy[l,l -biphenyl]-3,3 -diyl)bis-l-propanone, 2121... 

Hydroxy-4,8-dimethyl-6-propionylcoumarin. 7-Hydroxy-4,8-dimethyl-6-( 1 -oxopropyl)-2H-l -benzopyran-2-one, 2001... 

HYDROXY-3-(3-OXO-l -PHEN YLBUTYL)-2H-1 -BENZOPYRAN-2-ONE SODIUM S-ALT (9CI) see WAT220... 

SYNONYMS 3-(a-acetonylbenzyl)-4-hydroxycoumarin, 4-hydroxy-3-(3-oxo-l-phenyl-butyl)-2H-1 -benzopyran-2-one, warf. 

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