Hydrophobic group, presence

Through the presence of aromatic or pseudoaromatic groups in the molecule (tetraphenylborate and related derivatives, the tetraphenyl-arsonium ion, cationic triphenylmethane dyes, complexes of o-phenanthroline with divalent nickel or ion, where the hydrophobicity is increased by further substitution by a hydrophobic group on the pseudoaromatic nucleus). 

The results also indicated that the alkylic chain length and the hydrophobic group did not affect the formation of the nanoribbons. Their occurrence cannot be related to the maximum amount of surfactant adsorbed, i.e., 20, 9.5, 25, and 25% (m/m), for SDS, SOS, SDBS, and SOBS, respectively. The surfactants that presented a considerable amount of nanoribbons were SDS and SOBS, and the only plausible relation between them is that these surfactants have the closest CMCs (0.82 and 1.12 mol dm 3, respectively), again indicating that the presence of micelles in solution is essential to the formation of the nanoribbons. 

Recently performed studies on structure-activity relationships for inhibition of BCRP by flavonoids showed that the presence of the 2,3-double bond in ring C, ring B attached at position 2, an OH group at position 5, lack of hydroxylation at position 3, and hydrophobic groups substituted at positions 6, 7, 8, or 4 are favorable for BCRP modulation [239]. The studies were carried out with five flavonoid subclasses flavones, isoflavones, flavanones, flavonols, and chalcones (Figs. 2 and 6). For several compounds the 50% in-... 

It seems possible that the presence of a hydrophobic group, such as a phenyl, on the agonist at this location may be one feature which differentiates between an action at DA and DA2 receptors. Two prime examples to consider which seem paradoxical in this context are the l-phenyl-3-benzazepine XVI (SKF 38393) (35) and the 4-phenyl-l,2,3,4-tetrahydroisoquino-lines XVII (36). Both of these possess a phenyl ring which could project into the postulated hydrophobic region of the receptor. However, an analysis of the probable conformations... 

In many process situations, it is desirable that all or most proteins have minimal interaction with surfaces. In other cases, the surface interaction may serve as the primary mechanism of separation. What is the relationship between the physical and chemical structure of a surface and the partitioning of particular proteins to that surface How will a protein mixture partition in the presence of a surface with a certain density and organization of charges or hydrophobic groups What minimum of experimental data is required... 

The findings of the intensive QSAR analysis conducted by Rekker et al. [10] led to the conclusion that antihistaminic activity may be expected in compounds characterized by the presence of a hydrophobic group (the diaryl moiety) at a certain distance (the linker) from a positive charge (the basic function). The hydrophobic moiety is by far the most critical part for antihistaminic activity. In fact, the often-used term hydrophobic pocket is rather misleading, as the part of the receptor to... 

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