Hydrophobic brain

Soluble tetrameric form (G4) Composed of four identical monomers and stabilized by hydrophobic interactions of hydrophobic amino acids at the C terminus of monomers. Abundant for brain AChE and BChE in mammalian body fluids and in the soluble fraction of tissue homogenates. 

P., Ghlenov, M., McConnell, O., Ghait, A., Kipnis, V., Zaslavsky, B. Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLG. A simple model for predicting blood-brain distribution. Eur. J. Med. 

As stated earlier, the primary site of association of [ H]MDA with brain synaptosomes is with membrane components, not with the intrasynaptic space. While the phenolic ends of these compounds may enable them to interact with hydrophobic environments of brain membrane components, their polar side chains may inhibit the ability of these compounds to move freely across the membranes, thus inhibiting internalization. The pKa of... 

DMT, TMT, DBT, TBT and DPhT chlorides exhibited in vitro spindle disturbance in V79 Chinese hamster cells of brain tubulin. The V79 cells lose stainable spindles at higher concentration. The cell mitosis activity effect at low concentration increased with the lipophilicity of the OTC, but all compounds showed a concentration dependence on microtubules. The OTC seem to act through two different cooperative mechanisms inhibition of microtubule assembly and interaction with hydrophobic sites. The latter mechanism might involve Cl/OH ion exchange28. 

The hydrophobic components of many lipids consist of either isoprenoids or fatty acids and their derivatives 34 Isoprenoids have the unit structure of a five-carbon branched chain 34 Brain fatty acids are long-chain carboxylic acids that may contain one or more double bonds 34... 

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