Hydrolysis glycosidases

One of the most important differences between cellulose and starch is that animals can digest starch Because the glycosidic linkages m starch are a an animal s a glycosidase enzymes can catalyze then hydrolysis to glucose When more glucose is... 

Deoxyglycosides are, in spite of the 2000-fold greater sensitivity against acid hydrolysis, only poor substrates for glycosidases, as shown by the... 

Evidence for a glycosyl-enzyme intermediate of finite lifetime with inverting a-D-glycosidases, and details of its reaction, came from studies with 2,6-anhydro-l-deoxyhept-l-enitols and glycosyl fluorides. - Analysis of hydration and hydrolysis products on the one hand, and of glycosyla-tion products on the other, indicated an intermediate that could be approached by water from the yff-face only of the ring, and by other glycosyl acceptors only from the a-face (see Schemes 4 and 5 This can be considered a proof of the principle of microscopic reversibility of chemical reactions. 

RICHELLE M, PRIDMORE-MERTEN S, BODENSTAB S, ENSLEN M, OFFORD E A (2002) Hydrolysis of isoflavone glycosides to aglycones by (3-glycosidase does not alter plasma and urine isoflavone pharmacokinetics. J Nutr 132, 2587-92. 

Hydrolases lipase, protease, esterase nitrilase, nitrile hydratase glycosidase, phosphatase hydrolysis reactions in H20... 

S. Singh, M. Scigelova, and D. H. G. Crout, Glycosidase-catalysed synthesis of mannobioses by the reverse hydrolysis activity of alpha-mannosidase Partial purification of alpha-mannosidases from almond meal, limpets and Aspergillus niger, Tetrahedron Asymmetry, 11 (2000) 223-229. 

A Hydrolysis mechanism of retaining glycosidase (R = saccharide or alcohol) - double inversion at the anomeric centre. 

Scheme 2 Hydrolysis mechanisms of retaining (A) and inverting (B) glycosidase and P-A-acetylhexosaminidase, which uses a modified retaining mechanism (C).

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