Alpha mannosidase

S. Singh, M. Scigelova, and D. H. G. Crout, Glycosidase-catalysed synthesis of mannobioses by the reverse hydrolysis activity of alpha-mannosidase Partial purification of alpha-mannosidases from almond meal, limpets and Aspergillus niger, Tetrahedron Asymmetry, 11 (2000) 223-229. 

Cenci di Bello I, Fleet G Namgoong SK, Tadano K-I, Winchester B. (1989) Structure-activity relationship of swainsonine. Inhibition of human alpha-mannosidases by swainsonine analogues. BiochemJ 259 855-861. 

Nishio T, Hoshino S, Kondo A, Ogawa M, Matsuishi Y, Kitagawa M, Kawachi R, Oku T. alpha-Mannosidase-catalyzed synthesis of a (1 2)-alpha-D-rhamnodisaccharide derivative. Carbohydr. Res. 2004 339 1389-1393. 

Rizzolo, L. J., and Kornfeld, R. (1988). Post-translational protein modification in the endoplasmic reticulum. Demonstration of fatty acylase and deoxymannoiirimycin-sensitive alpha-mannosidase activities. J. Biol. Chem. 263, 9520-9525. 

Camirand, A., Heysen, A., Grondin, B., and Herscovics, A. (1991). Glycoprotein biosynthesis in Saccharomyces cerevisiae. Isolation and characterization of the gene encoding a specific processing alpha-mannosidase./. Biol. Chem. 266, 15120-15127. 

Chui D, Oh-Eda M, Liao YF, Panneerselvam K, Lai A, Marek KW, Freeze HH, Moremen KW, Fukuda MN, Marth JD. Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell 1997 90 157-167. 

N. Calculated two-dimensional sugar map of pyridylaminated oligosaccharides elucidation of the jack bean alpha-mannosidase digestion pathway of Man9GlcNAc2. Anal Biochem 1991 193 90-100. 

Indolizine is the core structure of many of the naturally occurring alkaloids such as swainso-nine (a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator and a potential chemotherapy drug), monomorine (might be used to lure ants to their doom), gephyrotoxin (muscarinic antagonist), and lamellarins (HIV-1 integrase inhibition and antibiotic activity) [6]. 

Kuntz DA, Nakayama S, Shea K, Hori H, Uto Y, Nagasawa H, Rose DR. Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase n. Chembiochem. 2010 ll(5) 673-680. 

Yamada, H., Nagai, T., Takemoto, N., Endoh, H., Kiyohara, H., Kawamura, H., Otsuka, Y Plantagoside, a novel alpha-mannosidase inhibitor isolated from the seeds of Plantago asiatica, suppresses immune response. Biochem. Biophys. Res. Commun. 3(165), 1292-1298(1989)... 

Yamashita, K., E. Ichishima, M. Arai, and A. Kobata, An alpha-mannosidase purified from Aspergillus saitoi is specific for al,2 linkages, Biochem. Biophys. Res. Common., 1980, 96. 1335 1342. 

Figure 2. Glycoprotein Processing Pathway. As described in the text, this pathway is initiated by transfer of Glc3Man9 GlcNAc)2 from lipid to protein in the ER. The initial removal of glucose and one mannose occurs in the ER, but removal of other mannose residues proceeds in the cis and medial Golgi apparatus by a number of alpha-mannosidase activities. Other processing reactions that go on in the medial and trans Golgi involve the addition of various sugars by individual and. specific glycosyltransferases.

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