Hydrogen Dihydrostreptomycin sulfate

Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium boro hydride reduction (Bristol), or by isolation from a fermentation process (Takeda). 

On catalytic hydrogenation absorbs approx one mole of hydrogen and forms dihydrostreptomycin B. Yields maltol on alkaline hydrolysis. When treated with dil acids liberates streptidine (or an isomer of it) isolated as the sulfate mono-hydrate, C8H,8N(04 H2SO4.HjO. 

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