Hydrogen bonds synthetic uses

Hydrogen bonds and metal coordination bonds have been the mainstay of the supramolecular chemist when it comes to the intentional manipulation of noncovalent interactions. However, nature s examples teach us the power of using weak, non-directional interactions to stabilize the folded state and deepen the folding funnel. Thus, van der Waals and solvophobic interactions are crucial to foldamer design, although they have been scarcely utilized in synthetic systems. In the simplest sense, such input is realized by incorporating amphiphilic character into the chain. 

We begin with a discussion of hydrogenation, focusing on the details of catalytic activation. Then we turn to the largest class of addition processes, those in which electrophiles such as protons, halogens, and metal ions are added to the alkene. Other additions that will contribute further to our synthetic repertoire include hydroboration, several oxidations (which can lead to complete mpture of the double bond if desired), and radical reactions. Each of these transformations takes us in a different direction the Reaction Summary Road Map at the end of the chapter provides an overview of the interconversions leading to and from this versatile compound class. 

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