Hydrogen bonds in proteins

Peters, D., and J. Peters. 1980b. Quantum Theory of the Structure and Bonding in Proteins Part 6. Factors governing the formation of hydrogen bonds in proteins and peptides. J. Mol. Struct. 68, 255-270. 

Pentynoic acid, 5 34t People. See also Personnel investment in, 21 624 organizational ties to, 21 627-628 People s Republic of China. See also China demand for oil in, 23 530 oil recovery program in, 23 534 Pepper, pipeline levels in, 23 159 Peptide antibiotics, 18 252-253. See also Antimicrobial peptides Peptide backbone hydrogen bonds, in proteins, 20 826 Peptide mapping, 3 840-841 Peptide nucleic acids, 17 631-634... 

Pierce, A.C., Sandretto, K.L., and Bemis, G.W. Kinase inhibitors and the case for CH... O hydrogen bonds in protein-ligand binding. Proteins Struc., Func., Genet. 2002, 49, 567—576. 

The protons participating in hydrogen bonding in proteins are only released if their associated hydrogen bonds are broken and if there is direct access to additional hydrogens from the solvent. This is illustrated in the following scheme ... 

Experimental 3hJ(P,N) couplings across N-H-O-P and 2hJ(P, H) across both N-H-O-P and O-H-O-P hydrogen bonds in protein nucleotide complexes were first reported independently by Riiterjans et al.135 and by Mishima et al.136 For instance, these authors measured the absolute values of 3hJ(P,N) = 4.44 0.06 and 2hJ(P,H) = 3.9 0.8 Hz between Ala 18 and the a-phosphate in wild-type Ras.GDP. Observations made by Mishima et al.136 led them to suggest that 3hJ(P,N) couplings are sensitive to the linear... 

It was suggested earlier that hydrogen bonds in proteins are the main contributors to the denaturation enthalpy at 7X, whereas the nonpolar contacts determine only the temperature dependence of the denaturation enthalpy (Privalov, 1979). The main argument for this was the observation that proteins that have the same enthalpies at Tx have an almost equal concentration of intramolecular hydrogen bonds, but differ in the concentration of nonpolar contacts (Table I). As is evident, the assumption of the dominant role of hydrogen bonds in the stabilization of protein structure explained the observed temperature convergence of the denaturation enthalpy, if the enthalpy of exposure of nonpolar groups to water is zero at this temperature. This assumption implied that either the enthalpy of... 

The identification of hydrogen bonds in proteins is, as in small molecule X-ray... 

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