Hydrogen Bond Donor Features of HFIP

For understanding the catalytic properties of H FIP, it is necessary to take a closer look at the hydrogen bond donor properties of HFIP, and the factors they are influenced by [35]. The hydrogen bond donor ability of fluorinated alcohols, and in particular HFIP, is mainly dependent on two parameters (i) the conformation of the alcohol monomer along the C—O bond [35, 36] and (ii) the cooperative aggregation to hydrogen bonded alcohol clusters [35]. 

Therefore, the following mechanistic investigation of the epoxidation of olefins with hydrogen peroxide is constrained to reaction pathways which (i) involve HFIP in an sc or even sp conformation and (ii) to hydrogen-bonded HFIP aggregates comprising up to four alcohol monomers. 

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A Detailed Look at the Hydrogen Bond Donor Features of HFIP... 

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