Hydrogel Clinical Applications

The hydrogel which has high compatable with skin was readily suitable for biomedical applications. In particular, nanosilver-based wound dressings have received approval for clinical applications. Therefore, the combination of a gel system with silver nanoparticles is considered a better choice for the treatment of wounds. Silver-based nanostructure materials have gained much attention in controlling infections in wounds. 

---

Clinical applications of thermosensitive hydrogels based on NIPAAm and its derivatives have limitations [121], The monomers and cross-linkers used in the synthesis of the hydrogels are still not known to be biocompatible and biodegradable. The observation that acrylamide-based polymers activate platelets upon contact with blood, together with the unclear metabolism of poly(NIPAAm), requires extensive toxicity studies before clinical applications can merge. 

S. Nagaoka and A. Nakao. Clinical application of antithrombogenic hydrogel with long poly(ethylene oxide) chains. Biomaterials 11 119-121 (1990). 

Fig. 7.4 Bio-inspired 3D liver detoxification device. Polydiacetylene nanoparticles (greeri) are installed in poly(ethylene glycol) diacrylate hydrogel matrix (grey) with liver-mimetic 3D structure fabricated by 3D printing. The nanoparticles attract, capture and sense toxins (red), while the 3D matrix with modified liver lobule structure allows toxins to be trapped efficiently. This biomimetic 3D detoxifier has promising clinical application for detoxification by collecting and removing toxins. Reproduced from [164]...

---