Hydrocholeretic effect

Hepatic cell injury induced by CCU, dimethyl nitrosamine, or thio-acetamide is accompanied by a reduced secretion of biliary components whereas ductular proliferation is observed after chronic administration of -naphthoisothiocyanate which also exerts a hydrocholeretic effect (G8). All these compounds tend to increase plasma retention of BSP. 

S. sclarea oil, administered by parenteral route in rats to obtain a stronger reaction closer to the effect produced by continued oral treatment, had a weak effect on choleretic activity and was substantially hydrocholeretic... 

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