Hydrochloride dihydrate

Naltrexone hydrochloride dihydrate (l-7V-cyclopropylmethyl-7,8-dihydro-14-hydroxy-morphinan-6-one hydrochloride) [16676-29-2] M 413.9, m 274-276°, [a] -173° (c 1, H2O), pKEst(i) 6 (N-cyclopropylmethyl), pKEst(i) (phenolic OH). This narcotic antagonist has been purified by recrystn from MeOH and dried air. The free base has m 168-170° after recrystn from Me2CO. [Cone et al. J Pharm Sci 64 618 7975 Gold et al. Med Res Rev 2 211 7952.]... 

D,L-Homatropine hydrobromide [51-56-9] Morphine sulfate [64-31-3] (55) Naloxone hydrochloride dihydrate [51481-60-8] 1882B I(2)286A, N(2)274C YM5602000, USP QC8750000, USP QD2275000, USP... 

AlPHAj-adrenergic blocking agents doxazosin mesylate prazosin hydrochloride terazosin hydrochloride dihydrate... 

Naltrexone hydrochloride dihydrate (17-[cyclopropylmethyl]-4,5-epoxy-3,14-dihydroxy-... 

Methenyl-5,6,7,8-tetrahydrofolic acid, chloride hydrochloride dihydrate... 

Methenyl-5,6,7,8-tetrahydrofolic acid, chloride hydrochloride dihydrate (20 g) was added in one portion to 100 ml water at 60°C followed by N,N-diethylethanolamine (14.9 g) which adjusted the pH to 6. The mixture was maintained at reflux for 5 hours and the pH kept between 5.7 and 6.2 by addition of N,N-diethylethanolamine. The mixture was cooled, synthetic magnesium silicate (15 g) added and slurried, and filtered through celite and diluted with 40 ml SD3A (95% ethanol with 5% methanol). The filtrate was kept at -5°C for 16 hours, aqueous calcium chloride (4.0 g) was added dropwise to the cold filtrate, and the precipitate filtered, washed with SD3A (100 ml) and with ethyl acetate (100 ml) and dried under reduced pressure. 

Preparation of 9-methyl-3-[(2-methyl-l-H-imidazol-l-yl)methyl]-l,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dihydrate The process above described is followed, except that after cooling down the reaction mixture to room temperature after boiling, 20 ml of 37% aqueous hydrochloric acid are added thereto. Then, the precipitate is filtered off, washed with isopropanol and dried to obtain 2.40 g (65.6%) of the title salt, m.p. 178°-180°C. The active agent content of the product was found to be 100.3% based on potentiometric titration with sodium hydroxide solution. The theoretical water content is 9.85% (calculated for C18H19N30HCl2H20).The water content measured is 10.03%. 

To a solution of n-butanol (316 ml), water (24 ml) and N-(2-tetrahydrofuroyl)piperazine (20 g) were added, while stirring, 4-amino-2-chloro-6,7-dimethoxyquinazoline (22.2 g). The reaction mixture was heated to reflux and the reflux was maintained for about 9 h. Then the reaction mixture was cooled to room temperature and stirred at this temperature for about 10-12 h. The crystals were collected by filtration, washed with n-BuOH and dried in vacuo at 40-50°C to yield 40.1 g (94%) of the l-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydrofuroyl)piperazine hydrochloride dihydrate... 

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