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Hybrid diffusion sequences

DNA end. A slightly different type of PNA consists of amino adds with nudeobases in their side chains. PNA bind strongly to complementary DNA and RNA sequences. The high metabolic stability renders PNA interesting for in-vivo applications. However, further modifications are required in order to make it suitable for treatment in eukaryotic cells because of a lacking diffusion across lipid membranes. PNA may be used in diagnostic techniques for the detection of specific DNA, as well as for site-specific labeling and hybridization of functional molecules to both DNA and RNA [T. Koch et al.. Nucleosides Nucleotides 1997,16, 1771 D. R. Corey, Trends Biotechnol. 1997, 15,224 E. Uhlmann, Biol. Chem. 1998,379,... [Pg.274]

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Hybridization sequencing

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