Hyaluronic acid drug delivery system

Richardson, J.L., and Armstrong, T.I., Vaginal Delivery of Calcitonin by Hyaluronic Acid Formulations. In Bioadhesive Drug Delivery Systems (E. Mathiowitz, D.E. Chickering, III, and C.-M. Lehr, eds.), Marcel Dekker, Inc., New York, 1999, pp. 563-599. 

Several other biodegradable, biocompatible, injectable polymers are being investigated for drug delivery systems. They include polyvinyl alcohol, block copolymer of PLA-PEG, polycyanoacrylate, polyanhydrides, cellulose, alginate, collagen, gelatin, albumin, starches, dextrans, hyaluronic acid and its derivatives, and hydroxyapatite. ... 

M.G. Cascone, L. Di Silvio, B. Sim, and S. Downes, Collagen and hyaluronic acid based polymeric blends as drug delivery systems for the release of physiological concentrations of growth hormone, /. Mater. Sci. Mater. Med., 5,770-774,1994. 

Recently, several other applications of hyaluronic acid in pharmaceutical science and practice have been considered and are highly prospective, such as the application of HA as a drug delivery system to increase drug efficacy, prolong their action, reduce side effects and so on. However, this is very wide topic that could be addressed in the separate monograph. 

Structure of (a) alginate (b) chitosan (c) hyaluronic acid, pH-responsive biopolymers used in drug delivery systems. 

Hyaluronic acid, (HA), also referred to as hyaluronan, is an important constituent of extracellular matrix, and has been used as a viscoelastic biomaterial for medical purposes, such as injectable fillers, and in drug delivery systems. The hyaluronan-based nerve conduit is not cytotoxic and shows good... 

Petersen, S., Kaule, S., Teske, M., et al. Development and in vitro characterization of hyaluronic acid-based coatings for implant-associated local drug delivery systems. J. Chem. (2013). doi 10.1155/2013/587875... 

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