Hyaluronan HYAFF

Different drug delivery systems have been proposed for vaginal delivery of peptides and proteins. The first one was a mucoadhesive gel based on polyacrylic acid intended for vaginal administration of insulin [96]. More recently, microparticulate systems such as starch and hyaluronan ester (HYAFF) microspheres have been proposed for vaginal delivery of insulin... 

Benedetti L, Cortivo R, Berti T, Berti A, Pea F, Mazzo M, Moras M, Abatangelo G. Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats. Biomaterials 1993 14 1154-1160. 

Moseley R, Leaver M, Walker M, Waddington RJ, Parsons D, Chen WY, Embery G. Comparison of the antioxidant properties of HYAFF-llp75, AQUACEL and hyaluronan towards reactive oxygen species in vitro. Biomaterials 2002 23 2255-2264. 

Grigolo B, Roseti L, Fiorini M, Fini M, Giavaresi G, Aldini NN, et al. Transplantation of chrondrocytes seeded on a hyaluronan derivative (HYAFF-ll)intocartilagedefectsinrabbits.B/omaferM/s2001 22(17) 2417-24. 

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