Hyaluronan free radical degradation

Hrabarova E, Katarina Valachova, Ivo Juranek, LadislavSoltes. Free-Radical Degradation of High-Molar-Mass Hyaluronan Induced by Ascorbate plus Cupric Ions Evaluation of Antioxidative Effect of Cysteine- Derived Compounds, CHEMISTRY BIODIVERSITY - Vol. 9 (2012). 

HrabdrovdE., ValachovdK., Juranek ., Soltes L. Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions. Anti-oxidative properties of the PieSt any-spa curative waters from healing peloid and maturation pool. In Kinetics, Catalysis and Mechanism of Chemical Reactions G. E. Zaikov (eds). Nova Science Publishers,New York, 2011 pp. 29-36. 

Soltes, L., and Kogan, G. Impact of transition metals in the free-radical degradation of hyaluronan biopolymer in the book "Kinetics Thermodynamics for Chemistry Biochemistry, Vol. 2 , pp. 181-199, E. M. Rearce, G. E. Zaikov, and G. Kirshenbaum, (Eds.), Nova Science Publishers, New York 2009, ibidPolym. Res. J., 2,269-288 (2008). 

Figure 4 Link protein (LP) function. LPs are depicted in two functional roles. (A) LP interacts with nascent aggrecan to induce a conformational change in the aggrecan G1 region to facilitate interaction with hyaluronan (HA). (B) LP present in proteoglycan aggregates protects the HA core from degradation by preventing access of hyaluronidases or free radicals.

Hyaluronan Degradation under Free-radical Oxidation Stress Action and Healing 109... 

Hyaluronan Degradation Under Free-Radical Oxidation Stress ... 

Fundamental research on the physico-chemical properties of HA is considered to have begun in 1951 with the publication of E.A. Balazs s article [11]. One of the first attempts to sterilize HA by UV light led to a complete loss of the solution viscosity. A similar result was obtained by A. Caputo in 1957 by X-ray exposure of the hyaluronan solution [12]. Later, it was found that when exposed to gamma radiation or electron beams, even at low initial levels of absorbed dose of ionizing radiation, HA degrades completely. The processes of polysaccharide radiolysis, which are associated with polymer degradation and involve free radicals, are now intensively studied in the radiochemistry of biomolecules. 

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