Hyaluronan clinical studies

I also held the Malcolm P. Aldrich Research Professorship. At that time it was the largest eye research institute affiliated with a clinical ophthalmology department in the country. The Columbia Connection held a special place of importance for me, since Karl Meyer had started his own research on hyaluronan there about 40 years earlier. Another famous biochemist was still at the Institute, Zacharias Dische, who made his fame studying glycoproteins. A few years later in 1977, I invited Karl Meyer to move back to the Eye Institute from Yeshiva University, which just closed its graduate program. He continued his research at the same place where he had started it 45 years previously imtil his death. 

Over the years, a number of clinical applications have been identified for human amnion membrane (HAM) [14-19]. Biomaterial studies of HAM show a high concentration of collagen and hyaluronan as well as small quantities of Proteoglycans in the matrix[20]. Although several studies have been done on Human amniotic membrane, none has explored the feasibility of fabricating it into a 3D scaffold. 

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