Hyaline inclusion bodies

Hepatic lesions in the case of yellow fever are more likely to correspond to those of hepatosis, (s. p. 404) There is also evidence of distinct acidophilic hepatocellular necrosis as well as microvesicular fatty degeneration of the hepatocytes. Hyaline, eosinophilic inclusions in the cytoplasm of degenerated hepatic cells (so-called Councilman bodies) are characteristic and were first identified by w.T. Councilman in 1890 in yellow fever (s. p. 396). Acidophilic inclusion bodies in the hepatocellular nuclei which are arranged concentrically around the nucleolus (so-called Torres corpuscles) correspond to the yellow fever virus (C.M. Torres, 1928). The liver does not present any significant signs of inflammation. The reticular fibre structure is maintained, so that the liver architecture is usually completely restored-provided the outcome of the disease is favourable, (s. fig. 23.4)... 

Hyaline cytoplasm inclusions (Mallory bodies) can often be detected. 

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