Pagiantha cerifera

Strychnine-Akuammicine-Ellipticine Group.—Very few new extractions have been recorded during the year under review. (- )-Akuammicine occurs in the leaves of Hunteria elliottii and in the aerial parts of V. major. A cytotoxic constituent of the roots of Tabernaemontana holstii K. Schum. proves to be tubotaiwine N-oxide. Olivacine and apparicine have been found in the leaves of Pagiantha cerifera. ... 

Ceridimine (303), from Pagiantha cerifera was the first example of a qua-sidimeric-type alkaloid in which the additional tryptamine unit has a free side chain and is linked by its aromatic moiety to the monoterpenoid indole unit 203). The primary amine function was readily acetylated and methylated, and its partial synthesis via coupling of vobasinol with tryptamine confirmed the structure assignment. Demethylceridimine (304) was later obtained from P. buchtieni T. buchtieni), which also provided another quasidimer, buchtienine (254) vide supra) 153). The third member of this group, hunteriatryptamine (305), was obtained from Hunteria zeylanica from Thailand. It differs from the previous two alkaloids by the presence of a hydroxymethyl function on the vobasinyl C(16) in place of H 204). 

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