Human serum chorionic gonadotrophin

Yagami, Y., and Ito, Y., 1965, Immunological assay of human serum chorionic gonadotrophin in normal and abnormal pregnancy. J. Jpn. Obstet. Gynecol. Soc. 12 82-88. 

Table 1.10. Some pharmaceutical substances originally isolated from animal sources. While some are still produced by direct extraction from the native source, others are now also produced by direct chemical synthesis (e.g. peptides and some steroids), or by recombinant DNA technology (most of the pol5 peptide products). Abbreviations hGH = human growth hormone FSH=follicle stimulating hormone hCG=human chorionic gonadotrophin HSA=human serum albumin HBsAg=hepatitis B surface antigen...

In a study of the relevance of the serum concentration of human chorionic gonadotrophin in 849 IVF cycles there were no significant relations between hCG concentrations and the proportion of follicles yielding oocytes, the fertilization rate, blastulation rate, or the probabilities of embryo transfer, implantation, or clinical pregnancy (32). This result again stresses the desirability of using moderate doses of hCG, which seems to reduce the risk of ovarian hyperstimulation while maintaining efficacy. 

Eu3+, Tb3+, Sm3+, Dy3+ complexes have different emission wavelengths with sharp peak profiles, which are suitable for multi-component immunoassay. Several Eu-Sm two-color time-resolved immunoassays have been reported. Since the sensitivity of Sm3+ chelates is not high compared to Eu3+ and Tb3+, Eu-Sm two-color assays are used for the simultaneous determination of a low concentration component (Eu) and a relatively high concentration component (Sm) in serum the assayed combinations are lutropin and follitropin, myoglobin and carbonic dehydratase, AFP and free (3-subunit of human chorionic gonadotrophin (Hemmila et al., 1987). Use of Eu-Tb is reported by Eriksson et al. (2000) for the simultaneous determination of human serum free and total PSA. 

Bl. Baechler, C., Bell, E. T., Borth, R., Brody, S., Carlstrom, G., Kerr, M. G., and Menzi, A., Comparison of two immunochemical and three biological methods for the assay of human chorionic gonadotrophin in serum. Acta Endocrinol. (Copenhagen) 61, 117-132 (1969). 

Electrochemical Chorionic gonadotrophin (human blood serum) Ferrocenecarboxylic acid conjugated with antihuman chorionic gonadotrophin immunoglobulin G antibody. Separation in a capillary column... 

Carcinoma, In some cases of testicular carcinoma, high urine levels of human chorionic gonadotrophin can be found. Serum a-fetoprotein levels may also be increased. 

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