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Human pharmacological activity monoclonal antibodies

Pharmacology Daclizumab is an immunosuppressive, humanized IgGI monoclonal antibody produced by recombinant DNA technology that binds specifically to the alpha subunit (Tac subunit) of the human high-affinity interleukin-2 (IL-2) receptor that is expressed on the surface of activated lymphocytes. Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. [Pg.1955]

Clinical pharmacology Basiliximab is a chimeric (mouse/human) interleukin-2 receptor antagonist. It is directed against the interleukin-2 receptor-alpha chain (CD25) on activated T-lymphocytes, and is a potent inhibitor of interleukin-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection. Another anti-CD25 monoclonal antibody, dacUzumab (Zenapax), has the same indication as basiliximab. [Pg.293]

See other pages where Human pharmacological activity monoclonal antibodies is mentioned: [Pg.199]    [Pg.569]    [Pg.645]    [Pg.181]    [Pg.307]    [Pg.1277]    [Pg.18]    [Pg.59]    [Pg.182]    [Pg.183]    [Pg.312]    [Pg.314]    [Pg.315]    [Pg.344]    [Pg.413]    [Pg.424]    [Pg.462]    [Pg.975]    [Pg.838]    [Pg.569]    [Pg.1422]    [Pg.22]    [Pg.203]    [Pg.218]    [Pg.24]   
See also in sourсe #XX -- [ Pg.360 , Pg.364 , Pg.371 , Pg.591 ]



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Activation antibodies

Active antibodies

Antibodies activity

Antibodies humanization

Human activities

Human pharmacological activity

Humanized antibodies

Humanized monoclonal antibodies

Monoclonal antibodies Human

Monoclonal human

Monoclonal humanized

Pharmacologic activity

Pharmacologically active

Pharmacology activity

Pharmacology human

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