Human genetics variable expression

Wojnowski L (2004) Genetics of the variable expression of CYP3A in humans. Ther Drag Monit 26 192-199... 

As described above, steroid hormones can affect many aspects of human behavior. However, correlations between specific steroid hormones and a given behavior often are weak. Many factors, including genetics, developmental experiences, cognitive states, and context variables determine human behavior, and may of course contribute to behavioral expression. 

The first two antibodies our group tried to express in this vector system within mammalian cells had mistakes in the genetic material that coded for variable regions and, consequently, did not express any antibody at all. The first antibody that was produced by recombinant technology at IDEC using this vector system was in early 1991. It was supposed to be a chimeric anti-CD4 antibody, but the antibody secreted by the cells did not bind to CD4. CD4 is a surface molecule on the leukocytes known as T cells. A primatized antibody (a chimeric antibody where the variable domains are isolated from a cynomol-gus monkey see Figure 32.2) to CD4 was produced later that year. That antibody ended up in clinical trials in humans at the same time as Rituxan. 

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