Human data meta-analysis

While comprehensive research and surveys were delayed, or lacking, no significant effort had been put toward the overview of the existing data of emissions, sources, distribution, exposure, and fate of POPs. Lee and Kim (1999) collected published data on concentrations of EDCs for almost all environmental media and human tissues and performed a meta-analysis to examine the relationship between the sperm quality of South Korean... 

Simmonds MC, et al. Safety and effectiveness of recombinant human bone morphogenetic Protein-2 for spinal FnsionA meta-analysis of individual-participant data. Ann Intern Med 2013 158 877-89. 

Octylcyanoacrylate is a medical grade topical tissue adhesive that has been approved for closing surgical incisions and traumatic lacerations. We reviewed animal and human studies that evaluated its use fora variety of surgical indications and specialties. We also performed a meta-analysis of all clinical trials using octylcyanoacrylate. Data sources ... 

RJ was studied in order to assess the size and consistency of its potential effect on serum lipids in experimental animals and humans. The data from animal studies were pooled, where possible, and statistically evaluated by Student s t-test, while meta-analysis was used for the evaluation of human trials. It was found that RJ significantly decreased serum and liver total lipids... 

FIGURE 6.2 Representation of multivariate data by icons, faces, and music for human cluster analysis and classification in a demo example with mass spectra. Mass spectra have first been transformed by modulo-14 summation (see Section 7.4.4) and from the resulting 14 variables, 8 variables with maximum variance have been selected and scaled to integer values between 1 and 5. A, typical pattern for aromatic hydrocarbons B, typical pattern for alkanes C, typical pattern for alkenes 1 and 2, unknowns (2-methyl-heptane and meta-xylene). The 5x8 data matrix has been used to draw faces (by function faces in the R-library Tea-chingDemos ), segment icons (by R-function stars ), and to create small melodies (Varmuza 1986). Both unknowns can be easily assigned to the correct class by all three representations. 

Recent meta-analyses of randomized trials of colloid administration to human critical care patients demonstrated no advantage of colloids over crystalloids and concluded that colloids increased mortality when used in some clinical syndromes (Choi et al 1999, Schierhout Roberts 1998). When trauma patients were studied as a subpopulation, a 12.3% difference in mortality rate was identified in favor of crystalloid therapy. Conversely, analysis of pooled data from nontrauma patients identified a 7.8% difference in mortality rate in favor of colloid treatment (Velanovich 1989). The majority of clinical trials in these meta-analyses compared albumin with crystalloid solutions and thus these results should not discourage the use of hydroxyethyl starches in horses. 

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