Host-Guest Complexation Chemistry

In summary, for an enzyme model to be operative, a certain number of criteria, characteristic of enzyme catalysis, must be fulfilled, among which is substrate specificity—that is, selective differential binding. The enzymelike catalyst must also obey Michaelis-Menten kinetics (saturation behavior), lead to a rate enhancement, and show bi- and/or multifunctional catalysis (348). 

This chapter on enzyme models will start by describing the chemistry and properties of some man-made organic host molecules which possess the capacity of enantiomeric discrimination. Six additional aspects of enzyme models will be developed and other interesting and fascinating enzyme and coenzyme models will be presented in the forthcoming chapters, especially Chapter 7 on coenzyme design and function. 

The discovery in 1967 by C. J. Pedersen (132, 133) that crown ethers have the unique ability to form stable complexes with metal ions and primary alkyl ammonium cations opened new horizons in organic chemistry (352- 

For instance, a fundamental question in host design is that of the effect of preorganization of binding sites on binding ability. Another problem is that of the placement of substituents in positions that converge on the functional or binding sites of guest compounds (137). 

After many trials in the molecular design of chiral crown ethers, a 1,1 -binaphthyl unit incorporated in a macroring by substitution in the 2,2 -positions proves to possess the desirable properties. The naphthalene-containing system, chosen for practical and strategic reasons, imparts rigidity and lipophilicity to conventional cyclic polyethers. The synthesis of such a host is presented in Fig. 5.2. 

---

F. Vn gtie and E. Weber, eds., Host-Guest Complex Chemistry - Macroycles, Springer, BerHn-Heidelberg, 1985. 

Vogtle, F, (ed.) Host Guest Complex Chemistry I, Top. Curr. Chem. 98 (1981), Berlin Heidelberg New York, Springer-Verlag 1982... 

Painter, G. R. Pressman, B. C. (1982). Dynamic Aspects of Ionophore Mediated Membrane Transport , in Host Guest Complex Chemistry II, ed. F. Vogtle. Springer-Verlag, Berlin. 

F. Vogtle and E. Weber, Host Guest Complex Chemistry III, Topics in Current Chemistry 121, Springer Verlag, Berlin (1984). 

Host-Guest Complex Chemistry Vbgtle, F, Ed. Springer-Verlag Berlin, 1981, 1982, 1984. Vols. 1-3. 

D. J. Cram and K. N. Trueblood in Host-Guest Complex Chemistry , ed. F. 

Baldwin, J. E., Perlmutter, P. Bridged, Capped and Fenced Porphyrins, in Topics Current Chem. 121, Host Guest Complex Chemistry III (eds. Vogtle, F., Weber, E.), Berlin - Heidelberg - New York - Tokyo, Springer 1984... 

Host-Guest Complexes Chemistry. Springer-Verlag Chemie Berlin, 1981. 

Host-Guest Complexes Chemistry Macrocycles. (Edit. Vogtle, F. Weber, E.) Springer-Verlag Berlin, 1985. 

Cram, D. Trueblood, K. In Host Guest Complex Chemistry Macrocycles Synthesis, Structures, Application Vogtle, F. Webber E., Ed. Springer-Verley Berlin Heiddberg New York Tokyo, 1985. 

Cram DJ (1985) In Vogtle F, Weber, E (eds) Host guest complex chemistry, Macrocycles, Springer, Berlin Heidelberg New York, p 125... 

Tell me about how you entered this field of host-guest complexation chemistry. 

Host-Guest Complex Chemistry Macrocycles. Synthesis, Structures, Apphcation / Ed. by F.Vogtle and E. Weber, Springer Verlag, Heidelberg, 1985. 

---