Hortia

There are several alkaloids in the structure of which are both quinazoline and indole nuclei. Evodiamine (1001 R = H) and rutaecarpine (1002) were both isolated from the seeds of Evodia rutaecarpa about 1916 and synthesized in 1927. They were found subsequently to occur also in Xanthoxylum rhetsa, which in addition yielded rhetsinine (1001 R = OH) (59T(7)257). The plant Hortia arborea afforded two more related alkaloids, hor-tiacine and hortiamine, each characterized by a methoxy group in the benzene ring of the indole portion (60JA5187). 

Evodiamine, the alkaloid from the Chinese drug plant Evodia rutaecarpa Benth. and Hook., has also been called rhetsine and its oxidation product rhetsinine, which is also found in nature, was shown to be the diamide (53). Recently a hypotensive red alkaloid isolated from the Brazilian plant Hortia arborea Engl, was given the name hortiamine. Degradation and synthetic studies have shown it to possess the structure (55). It was found together with another... 

Hortiamine, which can lower blood pressure, is a red alkaloid and the major hypotensive component of the bark of the Brazilian plant Hortia arborea (Rutaceae). Chemically, it is 10-methoxy-14-methyl-5-oxo-5,7,8,14-tetrahydroindolo[2, 3 3,4]pyrido[2,l-6]quinazoline.43 When boiled with moist benzene it forms a yellow product, hydrated as shown in 44, and Amaxfalls from 411 nm to 375 nm. The anhydrous form is regenerated on gentle drying.71... 

These alkaloids occur in the genera Evodia, Hortia, and Zanthoxylum, all members of the Rutaceae, and are restricted to only a few species. Most of the other species in these genera that have been examined yield furoquinoline and acridine alkaloids. Table I is a record of the occurrences, along with empirical formulas and melting points, of the quinazolinocarboline alkaloids. They are all optically inactive except evodiamine, [a]i> +352° (acetone), which is easily racemized. Wuchuyine, C10H13O2N, mp 237°, [a]D — 18°, occurring in E. rutaecarpa (1), evidently... 

Rutaecarpine Evodia rutaecarpa, Hortia arborea Inactive as VAN-R antagonist... 

Rutaecarpine (Ranunculaceae) Evodia rutaecarpa, Hortia arborea COX-2 [AI]... 

H. robustum Hortia arborea Lunasia amara Blanco Melicope fareana Engl. 

Hortia braziliana Vel. Pentaceras australis Hook. f. Zanthoxylum (Xanthoxylum) budrunga Wall. c e... 

The Alkaloids of Hortia arborea Engl. J. Amer. Chem. Soc. 82, 5187... 

Evodia rutaecarpa Hook. f. Thoms. (10, 111, 209) Hortia arborea Engl. (151)... 

OMe Elaplophyllum bucharicum [34], H. bungei [23], Hortia longifolia [44], Pilocarpus grandiflorus [40]... 

Elaplophyllum dauricum [18], Elesperethusa cremilata [42], Hortia longifolia... 

H. thesioides [28], Hortia colombiana [32], Micromelum minutum [44], Neoraputia paraensis [38], Zanthoxylum beecheyanum (Z. arnottianum) [39], Z. coco [16], Z. simulans [27]... 

Montanine 2,4-diOMe Aegle marmelos [38], Hortia colombiana [32], Ruta montana [24]... 

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