Hormone structure

A. W. Norman, R. Bouillon, M. Thomasset, eds.. Vitamin D. A Pluripotent Steroid Hormone Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, May 1994, Walter de Gmyter, Berlin, 1994, p. 89. 

Figure 42-3. Cholesterol side-chain cleavage and basic steroid hormone structures. The basic sterol rings are identified by the letters A-D. The carbon atoms are numbered 1-21 starting with the A ring. Note that the estrane group has 18 carbons (Cl 8), etc.

Arnaud, C. D. Brewer, H. B. Jr. "Parathyroid Hormone Structure and Immunoheterogenelty" In Methods In Radioimmunoassay, Toxicology and Related Areas". Progress In Analytical Chemistry, pp. 45-75, Vol. 8, Simmons, I. L. and Ewing, 6. W., Editors, Plenum Press, New York and London, 1974. 

Haack M, Beck-Sickinger AG (2007) Multiple Peptide Synthesis to Identify Bioactive Hormone Structures. 278 243-288... 

STEROID HORMONES STRUCTURE AND CONFORMATION OF AGONISTS AND ANTAGONISTS... 

An excellent, authoritative, well-illustrated, clear introduction to hormone structure, synthesis, and action. 

Somatotropin (STH) (Growth hormone, GH somatotrophic hormone hypophyseal growth hormone) Structure Known and synthesized coiled, unbranched Promotes general growth of organism Promotes skeletal growth, protein anabolism, fat metabolism, carbohydrate metabolism, water, and salt meiabolism Relates with all vitamins in connection with growth actions... 

Suwan S., Isobe M., Yamashita O., Minakata H. and Imai K. (1994) Silkworm diapause hormone, structure-activity relationships indispensable role of C-terminal amide. Insect Biochem. Mol. Biol. 24, 1001-1007. 

The growth hormone structure established the architecture of the site I and II interactions in a homodimeric receptor complex. The viral and human IL-6 complexes with gplSO extend this paradigm to heterodimeric complexes but also elaborate the modular epitope concept by adding the site III. It is clear from the gplSO complexes that in the case of the HHV-8 IL-6, a site II is used for the gplSO GHR contact. In the human structure, a site I is used for the a. receptor and a site II is used for the gplSO GHR interaction. Similar to GH, in the human IL-6 structure, precomplexation... 

The synthetic peptide was then chromatographed using Cjg reversed phase HPLC. Native "oostatic factor" coeluted with the synthetic peptide indicating that "oostatic hormone" structure is NHj-Tyr-Asp-Pro-Ala-(Pro)j-COOH. A Corey-Pauling-Koltun (CPK) atomic model of the factor indicates that the carboxyl end of the molecule probably exhibits a left-handed helical conformation in solution due to the six proline residues (23). 

Therefore, changes in the relative binding affinities of thyroid hormone structures to receptors will ultimately depend upon the specific steric requirements of the binding site and the ability of the hormones to adopt the required conformation. 

A pro-drug is a substance that has no special biological activity per se but can be converted into an active drug by enzymic action in the body. Thus, all the initial proteins formed by ribosomal synthesis that contain a peptide hormone structure locked within their amino-acid sequence are analogous to pro-drugs. The hormones are released by the action of proteolytic enzymes. Usually, however, the term prodrug is restricted to artificially synthesised molecules that are acted upon by the... 

Cell Type Hormone Structure Structurally Analogous Hormones... 

Yokota, T. Kim, S.-K. Kosaka, Y. Ogino, Y. Takahashi, N. In Conjugated Plant Hormone, Structure, Metabolism and Function Schreiber, K. Schutte, H. E. Sembdner, G. Ed VEG Deutcher Verlag der Wissenchaften 1987 pp286-296. 

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