Hormonal Norgestrel

In a lawsuit involving the Ortho Pharmaceutical Corporation, the issue was whether Ortho s norgestimate infringed the patentee s claims to norgestrel under the doctrine of equivalence.5 Both compounds are progestin-type steroid hormones used as oral contraceptives. The two compounds share the same fused ring core... 

A related family of polymers is based on E-caprolactone (ester of hydroxy-6-caproic acid) microspheres of poly(e-caprolactone) homopolymer, and its copolymers with racemic lactic acid have also been used for pharmaceutical forms of controlled release (74,114). In fact, the degradation of poly(e-caprolactone) is similar to that of poIy(Iactic acid) different investigations (123) have shown that the requirements of hormonal contraceptive methods and the slow biodegradation of the polymer make poly( -caprolactone) panicularty useful in the controlled release of such drugs as progesterone, testosterone, norgestrel. or norethisterone from depot systems,... 

With regard to serum lipids and oral contraceptives much work has been devoted to finding out which hormones and which combinations are least prone to induce changes. Briggs (114 ) has provided data on the combination ethinyloestradiol (30 mg) and norgestrel (150 )ig) which seems to have a minimum effect on cholesterol and triglycerides. 

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