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Hormesis data

Upton AC. 2001. Radiation hormesis data and interpretations. Crit. Rev. Toxicol. 31 681-95... [Pg.195]

Despite these impediments to the acceptance of hormesis (even in the presence of compelling data), there are activities that suggest that the hormesis concept could be embraced by society. The widely accepted and well-established observation that ingestion of a daily glass or two of red wine reduces the risk of cardiovascular disease may have preconditioned society to consider the hormetic hypothesis for pollutants and radiation. In addition, the recognition that anticancer agents can both stimulate and inhibit tumor growth via an hormetic dose response may enhance the clinical interest in this concept. [Pg.192]

The data supporting the hormetic dose-response therefore not only far exceeds normal proof of concept criteria but have been employed in the development of drugs for numerous human conditions, thereby satisfying a stronger proof of application requirements. In head-to-head direct comparisons the hormesis model far outcompeted the threshold and linear at low dose models (Calabrese and Baldwin 2001, 2003c Calabrese et al. 2006). In fact, while the threshold model was shown to poorly predict below threshold responses the linear at low-dose models, the LNT models cannot be practically validated in either moderate or large-scale studies. [Pg.197]

The answer to the question we posed earlier in this essay is clear The time is ripe for including hormesis as the principal regulatory model because it is not conjectural and is based on data consistent with all criteria put forth in the EPA s causal arguments. Specifically, this answer is justified by the following findings ... [Pg.201]

Calabrese, E. J., Staudenmayer, J. W., Stanek, E. J., and Hoffmann, G. R. (2006). Hormesis outperforms threshold model in NCI anti-tumor drug screening data. Toxicol Sci 94, 368-378. [Pg.205]

How should the FDA address the question of hormesis in its data requirements and evaluation processes ... [Pg.102]

The above examples are just a few of the many studies that have shown that radiation health effects demonstrate a hormetic effect, a characteristic of most pharmaceuticals and even to many foods. Hormesis is the concept that large doses of a substance may be detrimental to health, but small doses are beneficial. The evidence for this knowledge was effectively presented in a text published in 1980, titled Radiation Hormesis, by Dr. T.D. Luckey, and in 1991 followed by the second edition [7]. This text included over 1000 references of data on radiation hormesis. [Pg.935]

Radiation hormesis has been demonstrated to be real phenomenon in experiments on plants, bacteria, insects, animals, and with epidemiological and demographic data from humans. Not only does hormesis apply to radiation but also to low doses of physical. [Pg.937]

Experimental data support the concept of radiation hormesis, and several review articles provide detailed evidence of this (Ren, 2006 Hoffman and Stempsev,... [Pg.442]


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