Holley

The 1968 Nobel Prize in physiology or medicine was shared by Robert W Holley of Cornell University for determining the nucleotide sequence of phenylalanine transfer RNA... 

LH Holley, M Karplus. Protein secondary structure prediction with a neural network. Proc Natl Acad Sci USA 86 152-156, 1989. 

Holley, C.A., Method for recovering carbon black from composites, US patent, 5,728,361, 1998. 

Yunginger JW, Nelson DR, Squillace DL, Jones RT, 21 Holley KE, Hyma BA, Biedrzycki L, Sweeney KG, Stumer WQ, Schwartz LB Laboratory investigation of deaths due to anaphylaxis. J Forensic Sci 1991 36 857-865. 

Powell. D.A. Walters, K. Duncan, S. and Holley, J.R. The effects of chlorpromazine and ( -amphetamine upon shock-elicited aggression. Psychopharmacologia 30 303-314, 1973. 

Hafner, E.W., Holley, B.W., Holdom, K.S. et al. (1991) Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. Journal of Antibiotics (Tokyo), 44, 349-356. 

Guan T Y and Holley R A (2003), Pathogen survival in swine manure environments and transmission of human enteric illness A review , Journal of Environmental Quality, 32 (2), 383-391. 

Astic, L., Saucier, D. and Holley, A. Topographical relationships between olfactory receptor cells and glomerular foci in the rat olfactory bulb. Brain Res. 424 144—152, 1987. 

E Sondheimer, RW Holley. Imides from asparagine and glutamine, (effect of alkali... 

C. E. Holley Jr., E. J. Huber Jr. Combustion Calorimetry of Metals and Simple Metallic Compounds. In Experimental Chemical Thermodynamics, vol. 1 Combustion... 

Moser, M. J., Holley, W. R., Chatterjee, A., and Mian, I. S. (1997). The proofreading domain of Escherichia coli DNA polymerase land other DNA and/ or RNA exonuclease domains. Nucleic Acids Res. 25, 5110-5118. 

Turchi J, Holley LA, Sarter M. (1995). Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats. Psychopharmacology (Berlin). 118(2) 195-205. 

For most of the history of mankind, unraveling the nucleotide sequence of even a quite small nucleic acid was a formidable undertaking. Following 7 years of labor, Robert Holley solved the first such structure, that for an alanine tRNA from yeast, in 1961. This molecule contains a linear chain of 76 nucleotides and includes some unusual bases, which actually help in base sequence determination. For this achievement, Holley shared the Nobel Prize in Physiology or Medicine in 1968. 

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