HOCTl

Bednarczyk D, Ekins S, Wikel JH and Wright SH. Influence of molecular structure on substrate binding to the human organic cation transporter, hOCTl. Mol Pharmacol 2003 63 489-98. 

Zhang, L., Schaner, M. E., Giacomini, K. M., Functional characterization of an organic cation transporter (hOCTl) in a transiently transfected human cell line (HeLa),... 

A from the center of a positive ionizable group was identified. However, its predictive performance on a test set consisted of eight structurally similar compounds was relatively poor. To achieve a computational model with greater predictability, a descriptor-based QSPR model was also developed. Descriptors related to molecular hydrophobicity as well as hydrogen bond donor, shape and charge features contributed to explain hOCTl inhibitor properties of the analyzed compounds. 

Phc. 10.1. flocjie, OBaTejii.HocTL cnmioBoro 3xa ana rerepoaaepHOH chctcmm AX. 

Wang L et al (2008) Expression of the uptake drug transporter hOCTl is an important clinical determinant of the response to imatinib in chronic myeloid leukemia Clin Pharmacol Ther 83 258-264... 

Schinkel AH, Jonker JW. Polymorphisms affecting function of the human organic cation transporter hOCTl (SLC22A1) What are the consequences Pharmacogenetics 2002 12 589-90. 

In marked contrast to the previous transporters, PLS and in particular the combination of 2D and 3D descriptors are preferable for the hOCTl inhibitors (Table 15.2, panel E). 

Transporters, such as P-gp, play a key role in modulating the availability of drugs following absorption in the intestine and can also expel them from the brain [175-177], Other transporters of interest were the monoamine recognizing serotonin and noradrenaline transporters [123,124] and hOCTl... 

Alpha-difluoromethylornithine CATl [117] Metformin hOCTl/PMAT [118]... 

Influence of Molecular Structure of Substrate Binding to the Human Organic Cation Transporter, hOCTl. 

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