Histones reverse transcriptase

Ge Z, Liu C, Bjorkholm M, Gruber A, Xu D (2006) Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation. Mol Cell Biol 26(l) 230-237 Giet R, Glover DM (2001) Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol 152(4) 669-682... 

In our recent studies we were fortunate to recruit experimental collaborators who have validated computational hits identified by virtual screening of commercially available compound libraries using rigorously validated QSAR models. Examples include anticonvulsants (25), HIV-1 reverse transcriptase inhibitors (32), D1 antagonists (33), antitumor compounds (34), beta-lactamase inhibitors (35), human histone deacetylase (HDAC) inhibitors... 

Wooten-Blanks, L.G., Song, P., Senkal, C.E., and Ogretmen, B. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. Faseb J, 21, 2007, 3386-3397. 

Many of these proteins (e.g., the TATA-box binding protein, catabolite activator protein, Cro, Arc repressor) bind to DNA with some sequence specificity and are involved in transcription initiation or repression. Others, involved in packaging (the histone core, Sac7d), are relatively sequence neutral in binding. Pro-tein-DNA interactions important in disease are also represented human immunodeficiency virus (HIV) type 1 reverse transcriptase bends DNA considerably upon binding [131], as does the tumor suppressor protein p53, which also increases DNA twisting [132]. 

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